SCHEMBL12110293

SCHEMBL12110293

Cc1c(Cl)c(Cl)c(C)c2c1C(=O)c1ccccc1C2=O

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 2/20 0.52
DNMT1 P26358 1/20 0.52
DNMT3L Q9UJW3 1/20 0.52
DNMT3A Q9Y6K1 1/20 0.52
CYP1A2 P05177 3/20 0.50
CYP1A1 P04798 1/20 0.50
MEN1 O00255 5/20 0.48
KMT2A Q03164 5/20 0.48
CDC25B P30305 4/20 0.48
ADORA2A P29274 3/20 0.47
MAPT P10636 7/20 0.47
ALDH1A1 P00352 5/20 0.47
TDP1 Q9NUW8 4/20 0.47
KDM4E B2RXH2 3/20 0.47
USP2 O75604 2/20 0.47
DUSP3 P51452 1/20 0.47
MAOA P21397 4/20 0.46
FGR P09769 1/20 0.46
PIM1 P11309 1/20 0.46
CSNK1A1 P48729 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9510889 0.83 MEN1 (0.55) IDO1DNMT1DNMT3LDNMT3ACYP1A2
SCHEMBL9803179 0.79 MAPT (0.54) IDO1CYP1A2MEN1KMT2ACDC25B
SCHEMBL6904553 0.78 IDO1 (0.59) IDO1DNMT1DNMT3LDNMT3ACYP1A2
SCHEMBL13479020 0.78 CYP1A1 (0.60) IDO1DNMT1DNMT3LDNMT3ACYP1A2
SCHEMBL8876460 0.78 CYP1A1 (0.60) IDO1DNMT1DNMT3LDNMT3ACYP1A2
SCHEMBL27706729 0.77 CYP1A1 (0.50) IDO1DNMT1DNMT3LDNMT3ACYP1A2
SCHEMBL10600205 0.77 CYP1A1 (0.50) IDO1DNMT1DNMT3LDNMT3ACYP1A2
SCHEMBL27539278 0.75 ALDH1A1 (0.53) IDO1DNMT1DNMT3LDNMT3ACYP1A2
SCHEMBL10340740 0.75 ALDH1A1 (0.62) IDO1DNMT1DNMT3LDNMT3ACYP1A2
SCHEMBL8845047 0.74 DNMT1 (0.54) IDO1DNMT1DNMT3LDNMT3ACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8465889-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2013-06-18 US disclosed
US-8465889-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2013-06-18 US disclosed
US-8435706-B2 2013-05-07 US disclosed
US-8435706-B2 2013-05-07 US disclosed
US-20110268472-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2011-11-03 US disclosed
US-20110268472-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2011-11-03 US disclosed