Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12123775 | 0.85 | CYP2D6 (0.65) | KMT2AALDH1A1MEN1SMN1; SMN2MAPT | |
| SCHEMBL519649 | 0.80 | GAA (0.71) | KMT2ANPC1ALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL18159075 | 0.79 | KMT2A (0.53) | KMT2ANPC1ALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL28515710 | 0.78 | ALDH1A1 (0.58) | KMT2ANPC1ALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL375129 | 0.77 | KDM4E (0.65) | KMT2ANPC1ALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL12856164 | 0.77 | ALDH1A1 (0.55) | KMT2ANPC1ALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL5189041 | 0.77 | ALDH1A1 (0.57) | KMT2ANPC1ALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL20033128 | 0.77 | PDK1 (0.55) | KMT2ANPC1ALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL4834964 | 0.76 | ALDH1A1 (0.66) | KMT2ANPC1ALDH1A1MEN1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7930353 | 0.76 | ALDH1A1 (0.67) | KMT2AALDH1A1SMN1; SMN2MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150290200-A1 | INTRACELLULAR KINASE INHIBITORS | PHARMACYCLICS INC (US) | 2015-10-15 | — | — | US | disclosed |
| US-20140080833-A1 | INTRACELLULAR KINASE INHIBITORS | MANNKIND CORPORATION (US) | 2014-03-20 | — | — | US | disclosed |
| US-20110281850-A1 | INTRACELLULAR KINASE INHIBITORS | MANNKIND CORPORATION (US) | 2011-11-17 | — | — | US | disclosed |
| US-20070293499-A1 | Intracellular Kinase Inhibitors | MANNKIND CORPORATION (US) | 2007-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293499-A1 | Intracellular Kinase Inhibitors | PI4KB, BTK, LTK | KMT2A 1458/4885NPC1 3708/4885ALDH1A1 4370/4885 |
| US-20150290200-A1 | INTRACELLULAR KINASE INHIBITORS | PI4KB, BTK, LTK | KMT2A 1458/4885NPC1 3708/4885ALDH1A1 4370/4885 |
| US-20110281850-A1 | INTRACELLULAR KINASE INHIBITORS | PI4KB, BTK, LTK | KMT2A 1458/4885NPC1 3708/4885ALDH1A1 4370/4885 |
| US-20140080833-A1 | INTRACELLULAR KINASE INHIBITORS | PI4KB, BTK, LTK | KMT2A 1458/4885NPC1 3708/4885ALDH1A1 4370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.