Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 9/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.50 |
| ▸ | MAPKAPK3 | Q16644 | 5/20 | 0.50 |
| ▸ | MAPK6 | Q16659 | 5/20 | 0.50 |
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.50 |
| ▸ | MAPKAPK5 | Q8IW41 | 3/20 | 0.50 |
| ▸ | ITK | Q08881 | 5/20 | 0.46 |
| ▸ | FADS1 | O60427 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12090196 | 0.85 | ITK (0.47) | MAP2K4MAPK1MAPKAPK3MAPK6MAPKAPK2 | |
| SCHEMBL12120600 | 0.81 | HTR1D (0.41) | KDM4EALDH1A1MAPTGSK3B | |
| SCHEMBL14265487 | 0.81 | MAP2K4 (0.47) | MAP2K4MAPK1MAPKAPK3MAPK6MAPKAPK2 | |
| SCHEMBL7136525 | 0.80 | MAPK1 (0.45) | MAP2K4MAPK1MAPKAPK3MAPK6MAPKAPK2 | |
| SCHEMBL22890815 | 0.80 | GSK3B (0.59) | MAPK1KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL877445 | 0.80 | PDPK1 (0.58) | MAPK1FADS1MAPTHPGDCHEK1 | |
| SCHEMBL17229811 | 0.80 | FADS1 (0.45) | FADS1MAPTHPGDCHEK1GSK3B | |
| SCHEMBL29643965 | 0.80 | GSK3B (0.59) | MAPK1KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL12963901 | 0.80 | ITK (0.43) | MAP2K4ITKFADS1ACHEGSK3B | |
| SCHEMBL14158277 | 0.77 | KDM4E (0.50) | ITKFADS1KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110269958-A1 | PYRIDONS AS PDK1 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-11-03 | — | — | US | disclosed |
| US-20110224197-A1 | PYRIMIDINES AND PYRIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224197-A1 | PYRIMIDINES AND PYRIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES | GSK3B, CDK3, GSK3A | MAP2K4 61/4885MAPK1 285/4885MAPKAPK3 49/4885 |
| US-20110269958-A1 | PYRIDONS AS PDK1 INHIBITORS | PDK1, PDK2, PDK4 | MAP2K4 385/4885MAPK1 94/4885MAPKAPK3 202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.