Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 3/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.48 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | ITK | Q08881 | 6/20 | 0.37 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6370902 | 0.79 | AXL (0.54) | FGFR2FGFR3FGFR1MAPKAPK2CHEK1 | |
| SCHEMBL12120910 | 0.78 | ITK (0.42) | FGFR2FGFR3FGFR1MAPKAPK2CYP1A2 | |
| SCHEMBL381383 | 0.75 | IDO1 (0.58) | FGFR1MAPKAPK2CYP1A2CYP2D6ITK | |
| SCHEMBL3709693 | 0.74 | TTK (0.58) | FGFR2FGFR3FGFR1MAPKAPK2CHEK1 | |
| SCHEMBL5391597 | 0.73 | PDPK1 (0.56) | FGFR2FGFR3FGFR1CDK2GAA | |
| SCHEMBL30882695 | 0.73 | PDPK1 (0.56) | FGFR2FGFR3FGFR1CDK2GAA | |
| SCHEMBL5516155 | 0.72 | MAPKAPK2 (0.57) | MAPKAPK2ITKMAP2K4CDK2GSK3B | |
| Hydrochloric Acid SCHEMBL7425346 | 0.72 | PDPK1 (0.55) | FGFR2FGFR3FGFR1CDK2GAA | |
| Hydrochloric Acid SCHEMBL6371427 | 0.71 | MAPT (0.51) | MAPKAPK2CDK2PKMGSK3AGSK3B | |
| Hydrochloric Acid SCHEMBL6370465 | 0.71 | MAPK10 (0.68) | MAPKAPK2MAP2K4AXLPDPK1NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110269958-A1 | PYRIDONS AS PDK1 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-11-03 | — | — | US | disclosed |
| WO-2010007114-A2 | NEW CHEMICAL COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-01-21 | — | — | WO | disclosed |
| WO-2010007116-A2 | NEW CHEMICAL COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-01-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269958-A1 | PYRIDONS AS PDK1 INHIBITORS | PDK1, PDK2, PDK4 | FGFR2 2048/4885FGFR3 1552/4885FGFR1 694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.