Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 8/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 9/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14368882 | 0.83 | JAK2 (0.51) | MEN1NPC1ALDH1A1LMNAGAA | |
| SCHEMBL91579 | 0.82 | PDPK1 (0.55) | MEN1NPC1ALDH1A1LMNAGAA | |
| SCHEMBL1696402 | 0.82 | JAK2 (0.55) | MEN1NPC1ALDH1A1LMNAGAA | |
| SCHEMBL15601766 | 0.79 | PDPK1 (0.47) | ALDH1A1LMNAGAACYP1A2CYP2A6 | |
| SCHEMBL6478485 | 0.76 | JAK2 (0.66) | JAK2PDPK1AURKBAURKATGFBR1 | |
| SCHEMBL14346059 | 0.75 | MITF (0.43) | ALDH1A1KMT2APTK2BJAK2PDPK1 | |
| SCHEMBL6479588 | 0.74 | GSK3B (0.61) | CYP1A2JAK2CDK1CDK2TYK2 | |
| SCHEMBL6486529 | 0.73 | GSK3B (0.63) | JAK2PDPK1TYK2JAK3FGFR1 | |
| SCHEMBL5421465 | 0.72 | CYP1A2 (0.61) | MEN1NPC1ALDH1A1LMNAGAA | |
| SCHEMBL6890734 | 0.71 | CYP2A6 (0.73) | MEN1NPC1ALDH1A1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110281850-A1 | INTRACELLULAR KINASE INHIBITORS | MANNKIND CORPORATION (US) | 2011-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281850-A1 | INTRACELLULAR KINASE INHIBITORS | PI4KB, BTK, LTK | MEN1 1596/4885NPC1 3708/4885ALDH1A1 4370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.