Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 9/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 13/20 | 0.40 |
| ▸ | AURKA | O14965 | 5/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.40 |
| ▸ | JAK3 | P52333 | 3/20 | 0.39 |
| ▸ | CHUK | O15111 | 2/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14346062 | 0.83 | LRRK2 (0.47) | MITFALDH1A1TP53KMT2AJAK2 | |
| SCHEMBL1690470 | 0.82 | JAK2 (0.55) | MITFALDH1A1TP53KMT2AJAK2 | |
| SCHEMBL84515 | 0.82 | PDPK1 (0.55) | MITFALDH1A1TP53KMT2AJAK2 | |
| SCHEMBL15601766 | 0.79 | PDPK1 (0.47) | ALDH1A1JAK2PDPK1AURKAAURKB | |
| SCHEMBL6479720 | 0.76 | JAK2 (0.66) | MITFALDH1A1TP53KMT2AJAK2 | |
| SCHEMBL12907189 | 0.76 | JAK2 (0.66) | MITFALDH1A1TP53KMT2AJAK2 | |
| SCHEMBL12125261 | 0.75 | MEN1 (0.50) | ALDH1A1KMT2AJAK2PDPK1AURKA | |
| SCHEMBL19286495 | 0.74 | KIF11 (0.38) | MITFALDH1A1TP53KMT2A | |
| SCHEMBL29968032 | 0.73 | JAK2 (0.65) | JAK2PDPK1AURKBROCK1JAK3 | |
| SCHEMBL28871206 | 0.73 | JAK2 (0.65) | JAK2PDPK1AURKBROCK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070293499-A1 | Intracellular Kinase Inhibitors | MANNKIND CORPORATION (US) | 2007-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293499-A1 | Intracellular Kinase Inhibitors | PI4KB, BTK, LTK | MITF 3220/4885ALDH1A1 4370/4885TP53 605/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.