Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 2/20 | 0.37 |
| ▸ | DRD1 | P21728 | 2/20 | 0.35 |
| ▸ | AKT1S1 | Q96B36 | 5/20 | 0.34 |
| ▸ | KDR | P35968 | 4/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.33 |
| ▸ | RET | P07949 | 2/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.33 |
| ▸ | FLT1 | P17948 | 2/20 | 0.33 |
| ▸ | LTK | P29376 | 2/20 | 0.33 |
| ▸ | GRK5 | P34947 | 2/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.33 |
| ▸ | CDK8 | P49336 | 2/20 | 0.33 |
| ▸ | CDK7 | P50613 | 2/20 | 0.33 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL795294 | 0.75 | DRD1 (0.49) | NNMTDRD1AKT1S1KDRJAK2 | |
| SCHEMBL12127876 | 0.72 | ADK (0.43) | NNMTAKT1S1KDRJAK2CHEK1 | |
| SCHEMBL3803152 | 0.71 | NNMT (0.44) | NNMTDRD1AKT1S1KDRJAK2 | |
| SCHEMBL12832924 | 0.67 | MKNK1 (0.45) | NNMTDRD1AKT1S1KDRJAK2 | |
| SCHEMBL17041850 | 0.67 | NNMT (0.41) | NNMTDRD1AKT1S1KDRJAK2 | |
| SCHEMBL2600057 | 0.67 | DRD1 (0.49) | NNMTDRD1AKT1S1KDRJAK2 | |
| SCHEMBL16812277 | 0.67 | NNMT (0.41) | NNMTDRD1AKT1S1KDRJAK2 | |
| SCHEMBL17541159 | 0.64 | NNMT (0.60) | NNMTDRD1AKT1S1KDRJAK2 | |
| SCHEMBL5635227 | 0.64 | UHRF1 (0.49) | NNMTDRD1AKT1S1KDRJAK2 | |
| SCHEMBL12127625 | 0.64 | EGLN2 (0.33) | NNMTDRD1KDRMETGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110282056-A1 | PROTEIN KINASE INHIBITORS AND USE THEREOF | MERCK PATENT GMBH (DE) | 2011-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110282056-A1 | PROTEIN KINASE INHIBITORS AND USE THEREOF | MAP3K19, MAP3K20, MAP3K1 | NNMT 2232/4885DRD1 4851/4885AKT1S1 159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.