SCHEMBL121385

SCHEMBL121385

COC(=O)NNC(=O)c1cc(Br)cc(Br)c1NC(=O)c1cc(Br)nn1-c1ncccc1Cl

nearest known ligand 0.60

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 3/20 0.41
ALDH1A1 P00352 1/20 0.35
MALT1 Q9UDY8 9/20 0.34
LRRK2 Q5S007 1/20 0.33
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
RBP4 P02753 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31438693 1.00 DHODH (0.41) DHODHALDH1A1MALT1LRRK2MEN1
SCHEMBL13073075 0.93 DHODH (0.41) DHODHALDH1A1MALT1MEN1KMT2A
SCHEMBL13072911 0.92 DHODH (0.40) DHODHALDH1A1MALT1MEN1KMT2A
SCHEMBL13318579 0.92 DHODH (0.40) DHODHALDH1A1MALT1MEN1KMT2A
SCHEMBL12911637 0.91 DHODH (0.40) DHODHALDH1A1MALT1LRRK2MEN1
SCHEMBL13072526 0.91 DHODH (0.35) DHODHALDH1A1MALT1LRRK2MEN1
SCHEMBL12559867 0.90 DHODH (0.45) DHODHALDH1A1MALT1MEN1KMT2A
SCHEMBL15525072 0.90 DHODH (0.41) DHODHMALT1LRRK2MEN1KMT2A
SCHEMBL536164 0.90 DHODH (0.42) DHODHALDH1A1MALT1MEN1KMT2A
SCHEMBL13072488 0.89 DHODH (0.37) DHODHALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 237 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3646731-A1 PESTICIDAL MIXTURES COMPRISING A PYRAZOLE COMPOUND BASF SE (DE) 2020-05-06 EP claimed
EP-3300602-B1 PESTICIDAL MIXTURES COMPRISING A PYRAZOLE COMPOUND BASF SE (DE) 2020-03-25 EP claimed
EP-3300602-A1 PESTICIDAL MIXTURES COMPRISING A PYRAZOLE COMPOUND BASF SE (DE) 2018-04-04 EP claimed
US-20160219872-A1 Foamable Pesticide Compositions And Methods Of Application BASF CORPORATION 2016-08-04 US claimed
US-9339030-B2 Foamable pesticide compositions and methods of application BASF CORPORATION (US) 2016-05-17 US claimed
EP-2864320-A1 PYRAZOLE COMPOUND AND PESTICIDAL MIXTURES COMPRISING A PYRAZOLE COMPOUND BASF SE (DE) 2015-04-29 EP claimed
US-20150105258-A1 Methods For Controlling Pests BASF CORPORATION (US) 2015-04-16 US claimed
US-8980294-B2 Methods for controlling pests BASF CORPORATION (US) 2015-03-17 US claimed
US-8940662-B2 Methods for controlling pests BASF CORPORATION (US) 2015-01-27 US claimed
WO-2014063942-A1 SUBSTITUTED PESTICIDAL PYRAZOLE COMPOUNDS BASF SE (DE) 2014-05-01 WO claimed
JP-2011527307-A 2011-10-27 JP claimed
US-20110118212-A1 Pestcidal active mixtures comprising isoxazoline compounds I BASF SE (DE) 2011-05-19 US claimed
EP-2306837-A1 PESTCIDAL ACTIVE MIXTURES COMPRISING ISOXAZOLINE COMPOUNDS I BASF SE (DE) 2011-04-13 EP claimed
WO-2011025789-A2 FOAMABLE PESTICIDE COMPOSITIONS AND METHODS OF APPLICATION BASF CORPORATION (US) 2011-03-03 WO claimed
US-20100322892-A1 PESTICIDE COMPOSITIONS AND APPLICATORS BASF CORPORATION (US) 2010-12-23 US claimed
US-20100323897-A1 FOAMABLE PESTICIDE COMPOSITIONS BASF CORPORATION (US) 2010-12-23 US claimed
US-20100322990-A1 METHODS FOR CONTROLLING PESTS BASF CORPORATION (US) 2010-12-23 US claimed
WO-2010129345-A2 FOAMABLE PESTICIDE COMPOSITIONS BASF CORPORATION (US) 2010-11-11 WO claimed
WO-2010127019-A1 PESTICIDE COMPOSITIONS AND APPLICATORS BASF CORPORATION (US) 2010-11-04 WO claimed
WO-2010003923-A1 PESTCIDAL ACTIVE MIXTURES COMPRISING ISOXAZOLINE COMPOUNDS I BASF SE (DE) 2010-01-14 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100323897-A1 FOAMABLE PESTICIDE COMPOSITIONS DDT, PON1, ACHE DHODH 718/4885ALDH1A1 2775/4885MALT1 4476/4885
US-20110118212-A1 Pestcidal active mixtures comprising isoxazoline compounds I CHRM3, CHRM5, CHRM1 DHODH 4306/4885ALDH1A1 2108/4885MALT1 4326/4885
US-20100322990-A1 METHODS FOR CONTROLLING PESTS DDT, ACHE, PON1 DHODH 1877/4885ALDH1A1 3222/4885MALT1 4338/4885
US-20100322892-A1 PESTICIDE COMPOSITIONS AND APPLICATORS DDT, ACHE, CHRM2 DHODH 2887/4885ALDH1A1 2417/4885MALT1 2349/4885
US-20150105258-A1 Methods For Controlling Pests DDT, ACHE, PON1 DHODH 1877/4885ALDH1A1 3222/4885MALT1 4338/4885
US-20160219872-A1 Foamable Pesticide Compositions And Methods Of Application DDT, PLD1, ACHE DHODH 1116/4885ALDH1A1 3494/4885MALT1 3749/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.