⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15834582 | 0.85 | — | — | |
| SCHEMBL23810488 | 0.81 | ALDH1A1 (0.45) | — | |
| SCHEMBL150973 | 0.77 | TDP1 (0.45) | — | |
| SCHEMBL209638 | 0.74 | — | — | |
| SCHEMBL764602 | 0.74 | — | — | |
| SCHEMBL12012311 | 0.74 | — | — | |
| SCHEMBL12530457 | 0.73 | MAPK1 (0.30) | — | |
| SCHEMBL19319078 | 0.73 | ALDH1A1 (0.36) | — | |
| SCHEMBL22149963 | 0.73 | MEN1 (0.50) | — | |
| SCHEMBL23841863 | 0.73 | EPHX2 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11912708-B2 | Macrocyclic heterocycles and uses thereof | KUMQUAT BIOSCIENCES INC. (US) | 2024-02-27 | — | — | US | disclosed |
| US-20230339952-A1 | MACROCYCLIC HETEROCYCLES AND USES THEREOF | KUMQUAT BIOSCIENCES INC. | 2023-10-26 | — | — | US | disclosed |
| WO-2014100719-A2 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2014-06-26 | — | — | WO | disclosed |
| US-20130172349-A1 | INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE | NOVARTIS AG (CH) | 2013-07-04 | — | — | US | disclosed |
| US-8404684-B2 | Inhibitors of phosphatidylinositol 3-kinase | NOVARTIS AG (CH) | 2013-03-26 | — | — | US | disclosed |
| US-20110288337-A1 | PROCESS FOR PREPARING 2-(2-TERT-BUTYLAMINOETHOXY)ETHANOL (TERT-BUTYLAMINODIGLYCOL, TBADG) | BASF SE (DE) | 2011-11-24 | — | — | US | disclosed |
| US-20080139493-A1 | Bi- or Tetra-Guanidino-Biphenyl Compounds as Small Molecule Carriers | UCL BUSINESS PLC (GB) | 2008-06-12 | — | — | US | disclosed |