Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 14/20 | 0.42 |
| ▸ | RAB9A | P51151 | 14/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | IL2 | P60568 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12241434 | 0.92 | IL2 (0.46) | NPC1RAB9ASMN1; SMN2MAPTNPSR1 | |
| SCHEMBL1702038 | 0.91 | SMN1; SMN2 (0.52) | NPC1RAB9ASMN1; SMN2MAPTNPSR1 | |
| SCHEMBL12155617 | 0.88 | RAB9A (0.43) | NPC1RAB9ASMN1; SMN2MAPTNPSR1 | |
| SCHEMBL12156237 | 0.88 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2MAPTNPSR1 | |
| SCHEMBL12241439 | 0.87 | IL2 (0.44) | NPC1RAB9ASMN1; SMN2MAPTNPSR1 | |
| SCHEMBL12155520 | 0.86 | L3MBTL1 (0.47) | NPC1RAB9ASMN1; SMN2TP53IL2 | |
| SCHEMBL12155512 | 0.86 | MAPT (0.43) | NPC1RAB9ASMN1; SMN2MAPTNPSR1 | |
| SCHEMBL12155603 | 0.85 | IL2 (0.43) | NPC1RAB9ASMN1; SMN2MAPTNPSR1 | |
| SCHEMBL12156212 | 0.84 | SMN1; SMN2 (0.48) | NPC1RAB9ASMN1; SMN2MAPTNPSR1 | |
| SCHEMBL12155931 | 0.84 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2TP53IL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563776-B1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA INC (US) | 2016-06-08 | — | — | EP | disclosed |
| US-9120751-B2 | Compounds that modulate intracellular calcium | CALCIMEDICA, INC. (US) | 2015-09-01 | — | — | US | disclosed |
| US-9120751-B2 | Compounds that modulate intracellular calcium | CALCIMEDICA, INC. (US) | 2015-09-01 | — | — | US | disclosed |
| US-8980629-B2 | Compounds that modulate intracellular calcium | CALCIMEDICA, INC. (US) | 2015-03-17 | — | — | US | disclosed |
| WO-2011139489-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA INC. (US) | 2011-11-10 | — | — | WO | disclosed |