Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 6/20 | 0.48 |
| ▸ | ORAI1 | Q96D31 | 6/20 | 0.48 |
| ▸ | IL2 | P60568 | 8/20 | 0.42 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 5/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12156163 | 0.92 | STIM1 (0.42) | STIM1ORAI1IL2ABL1 | |
| SCHEMBL12155918 | 0.89 | IL2 (0.54) | STIM1ORAI1IL2ORAI2ABL1 | |
| SCHEMBL17805351 | 0.88 | STIM1 (0.47) | STIM1ORAI1IL2ORAI2 | |
| SCHEMBL12156225 | 0.83 | STIM1 (0.54) | STIM1ORAI1IL2ORAI2ABL1 | |
| SCHEMBL14239062 | 0.83 | STIM1 (0.66) | STIM1ORAI1IL2ORAI2ABL1 | |
| SCHEMBL16572573 | 0.81 | IL2 (0.46) | STIM1ORAI1IL2ORAI2ABL1 | |
| SCHEMBL12156168 | 0.79 | STIM1 (0.41) | STIM1ORAI1IL2ORAI2ABL1 | |
| SCHEMBL12155594 | 0.79 | IL2 (0.57) | STIM1ORAI1IL2ORAI2ABL1 | |
| SCHEMBL17805360 | 0.78 | STIM1 (0.46) | STIM1ORAI1IL2ORAI2ABL1 | |
| SCHEMBL12241381 | 0.77 | STIM1 (0.50) | STIM1ORAI1IL2ORAI2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011139489-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA INC. (US) | 2011-11-10 | — | — | WO | disclosed |