Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 6/20 | 0.66 |
| ▸ | ORAI1 | Q96D31 | 6/20 | 0.66 |
| ▸ | IL2 | P60568 | 6/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12156225 | 0.90 | STIM1 (0.54) | STIM1ORAI1IL2ORAI2ABL1 | |
| SCHEMBL12155891 | 0.87 | STIM1 (0.66) | STIM1ORAI1IL2NPC1RAB9A | |
| SCHEMBL12155568 | 0.85 | STIM1 (0.64) | STIM1ORAI1IL2NPC1RAB9A | |
| SCHEMBL12156167 | 0.83 | STIM1 (0.48) | STIM1ORAI1IL2ORAI2ABL1 | |
| SCHEMBL12155499 | 0.81 | IL2 (0.59) | STIM1ORAI1IL2NPC1RAB9A | |
| SCHEMBL17805360 | 0.80 | STIM1 (0.46) | STIM1ORAI1IL2ORAI2ABL1 | |
| SCHEMBL12155936 | 0.80 | STIM1 (0.62) | STIM1ORAI1IL2NPC1RAB9A | |
| SCHEMBL12155795 | 0.80 | STIM1 (0.43) | STIM1ORAI1IL2NPC1RAB9A | |
| SCHEMBL14150171 | 0.80 | STIM1 (1.00) | STIM1ORAI1 | |
| SCHEMBL12241564 | 0.79 | IL2 (0.57) | STIM1ORAI1IL2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012170931-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2012-12-13 | — | — | WO | disclosed |