Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.50 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.44 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CPB2 | Q96IY4 | 3/20 | 0.39 |
| ▸ | CPB1 | P15086 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.34 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | RBP4 | P02753 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6335415 | 0.82 | SMYD3 (0.52) | SMYD3MAP3K5CYP2E1CYP3A4CYP2A6 | |
| SCHEMBL16566390 | 0.79 | SMYD3 (0.57) | SMYD3MAP3K5CYP2E1CYP3A4CYP2A6 | |
| SCHEMBL7425205 | 0.79 | SMYD3 (0.50) | SMYD3MAP3K5CYP2E1CYP3A4CYP2A6 | |
| SCHEMBL25153647 | 0.78 | NOTUM (0.51) | SMYD3MAP3K5ALDH1A1RAB9ANOTUM | |
| SCHEMBL27550007 | 0.78 | SMYD3 (0.46) | SMYD3MAP3K5CYP2E1CYP3A4CYP2A6 | |
| SCHEMBL16690901 | 0.75 | RBP4 (0.54) | CYP2E1CYP3A4CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL30162870 | 0.75 | SMYD3 (0.57) | SMYD3MAP3K5CPB2 | |
| SCHEMBL13925850 | 0.74 | SMYD3 (0.42) | SMYD3MAP3K5CYP2E1CYP3A4CYP2A6 | |
| SCHEMBL1614140 | 0.72 | — | — | |
| SCHEMBL15701590 | 0.72 | NPC1 (0.33) | SMYD3KCNJ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110269763-A1 | CRTH2 receptor ligands for medicinal uses | 7TM PHARMA A/S (DK) | 2011-11-03 | — | — | US | disclosed |
| US-20110269763-A1 | CRTH2 receptor ligands for medicinal uses | 7TM PHARMA A/S (DK) | 2011-11-03 | — | — | US | disclosed |
| US-8022063-B2 | CRTH2 receptor ligands for medicinal uses | 7TM PHARMA A/S (DK) | 2011-09-20 | — | — | US | disclosed |
| EP-2336113-A1 | CRTH2 Receptor Ligands for Medical Use | 7TM Pharma A/S (DK) | 2011-06-22 | — | — | EP | disclosed |
| US-20090099189-A1 | CRTH2 Receptor Ligands For Medicinal Uses | 7TM PHARMA A/S (DK) | 2009-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099189-A1 | CRTH2 Receptor Ligands For Medicinal Uses | HRH1, HRH2, HRH3 | SMYD3 2589/4885MAP3K5 3218/4885CYP2E1 721/4885 |
| US-20110269763-A1 | CRTH2 receptor ligands for medicinal uses | HRH1, HRH2, HRH4 | SMYD3 2945/4885MAP3K5 3174/4885CYP2E1 759/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.