Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.48 |
| ▸ | RELA | Q04206 | 2/20 | 0.48 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.47 |
| ▸ | PPARG | P37231 | 2/20 | 0.47 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10305623 | 0.85 | SERPINE1 (0.44) | RAB9ANPC1SMN1; SMN2SERPINE1POLB | |
| SCHEMBL10223720 | 0.83 | CCR9 (0.58) | — | |
| SCHEMBL14310306 | 0.82 | SERPINE1 (0.44) | RAB9ANPC1SMN1; SMN2SERPINE1POLB | |
| SCHEMBL29738283 | 0.80 | RAB9A (0.51) | RAB9ANPC1SMN1; SMN2L3MBTL1TP53 | |
| SCHEMBL28761420 | 0.80 | RAB9A (0.51) | RAB9ANPC1SMN1; SMN2L3MBTL1TP53 | |
| SCHEMBL10223770 | 0.77 | CCR9 (0.54) | ALDH1A1MAPTTP53KMT2ALMNA | |
| SCHEMBL12347492 | 0.77 | SMN1; SMN2 (0.48) | RAB9ANPC1SMN1; SMN2SERPINE1POLB | |
| SCHEMBL7303587 | 0.76 | RAB9A (0.68) | RAB9ANPC1SMN1; SMN2SERPINE1POLB | |
| SCHEMBL305646 | 0.76 | CCR9 (0.55) | MAPTTP53KMT2ALMNA | |
| SCHEMBL14303632 | 0.75 | MAPT (0.49) | RAB9ANPC1SERPINE1POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838674-B9 | HETEROARYL SULFONAMIDES AND CCR2 | CHEMOCENTRYX INC (US) | 2011-11-02 | — | — | EP | disclosed |
| EP-1838674-B1 | HETEROARYL SULFONAMIDES AND CCR2 | CHEMOCENTRYX INC (US) | 2011-03-30 | — | — | EP | disclosed |