SCHEMBL7303587

SCHEMBL7303587

CC(C)(C)c1ccc(C(=O)Nc2cc(Cl)ccc2Cl)cc1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 4/20 0.68
NPC1 O15118 2/20 0.68
ALDH1A1 P00352 2/20 0.68
GLA P06280 1/20 0.68
ATM Q13315 1/20 0.68
L3MBTL1 Q9Y468 1/20 0.68
SERPINE1 P05121 1/20 0.68
KMT2A Q03164 4/20 0.65
MEN1 O00255 3/20 0.65
SMN1; SMN2 Q16637 2/20 0.63
NR1H4 Q96RI1 5/20 0.63
PPARG P37231 4/20 0.63
HDAC1 Q13547 1/20 0.60
HDAC8 Q9BY41 1/20 0.60
HDAC6 Q9UBN7 1/20 0.60
POLB P06746 2/20 0.59
KDM4E B2RXH2 1/20 0.57
LMNA P02545 1/20 0.57
MAPT P10636 1/20 0.57
HPGD P15428 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7297665 0.88 SERPINE1 (0.72) RAB9ANPC1ALDH1A1GLAATM
SCHEMBL7293409 0.87 SERPINE1 (0.67) RAB9ANPC1ALDH1A1GLAATM
SCHEMBL7292066 0.87 KCNMA1 (0.69) RAB9ANPC1ALDH1A1GLAATM
SCHEMBL2347366 0.86 EPHX1 (0.72) RAB9ANPC1ALDH1A1GLAATM
SCHEMBL15149738 0.86 SERPINE1 (0.53) RAB9ANPC1ALDH1A1GLAATM
SCHEMBL7302295 0.85 SERPINE1 (0.65) RAB9ANPC1ALDH1A1GLAATM
SCHEMBL7299173 0.84 RAB9A (0.68) RAB9ANPC1ALDH1A1GLAATM
SCHEMBL7302951 0.84 SERPINE1 (0.71) RAB9ANPC1ALDH1A1GLAATM
SCHEMBL7301478 0.82 HDAC1 (0.69) RAB9ANPC1ALDH1A1GLAATM
SCHEMBL26074396 0.81 RAB9A (1.00) RAB9ANPC1ALDH1A1GLAATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0358118-B1 Phenylamides - process for their preparation as well as a drug containing those compounds BOEHRINGER MANNHEIM GMBH (DE) 1994-03-16 EP disclosed
US-5135949-A Anticoagulants BOEHRINGER MANNHEIM GMBH (DE) 1992-08-04 US disclosed
EP-0358118-A1 Phenylamides - process for their preparation as well as a drug containing those compounds Roche Diagnostics GmbH (DE) 1990-03-14 EP disclosed