Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 5/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12168922 | 0.88 | GHSR (0.49) | GHSRSCN5ASCN9ANR1H4ALDH1A1 | |
| SCHEMBL3638644 | 0.83 | GHSR (0.50) | GHSRSCN5ASCN9ANR1H4ALDH1A1 | |
| SCHEMBL4335252 | 0.82 | GHSR (0.50) | GHSRSCN5ASCN9ANR1H4ALDH1A1 | |
| SCHEMBL12168916 | 0.79 | SCN9A (0.43) | GHSRSCN5ASCN9ANR1H4ALDH1A1 | |
| SCHEMBL3638890 | 0.78 | GHSR (0.48) | GHSRSCN5ASCN9ANR1H4ALDH1A1 | |
| SCHEMBL12168915 | 0.77 | TDP1 (0.55) | GHSRNR1H4ALDH1A1L3MBTL1TSHR | |
| SCHEMBL12168892 | 0.77 | POLB (0.46) | GHSRSCN5ASCN9ANR1H4ALDH1A1 | |
| SCHEMBL16230424 | 0.76 | GHSR (0.52) | GHSRALDH1A1L3MBTL1TSHRTDP1 | |
| SCHEMBL3637567 | 0.75 | GHSR (0.51) | GHSRSCN5ASCN9ANR1H4ALDH1A1 | |
| SCHEMBL12188517 | 0.75 | GHSR (0.39) | GHSRSCN9ANR1H4ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8952042-B2 | FXR (NR1H4) binding and activity modulating compounds | PHENEX PHARMACEUTICALS AG (DE) | 2015-02-10 | — | — | US | disclosed |
| US-20120232116-A1 | NOVEL FXR (NR1H4) BINDING AND ACTIVITY MODULATING COMPOUNDS | PHENEX PHARMACEUTICALS AG (DE) | 2012-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120232116-A1 | NOVEL FXR (NR1H4) BINDING AND ACTIVITY MODULATING COMPOUNDS | NR1H4, NR1H2, NR1H3 | GHSR 385/4885SCN5A 2662/4885SCN9A 4060/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.