Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 5/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 7/20 | 0.48 |
| ▸ | PPARD | Q03181 | 2/20 | 0.48 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.47 |
| ▸ | FABP1 | P07148 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3638644 | 0.83 | GHSR (0.50) | GHSRNR1H4ALDH1A1LMNAGAA | |
| SCHEMBL12168922 | 0.83 | GHSR (0.49) | GHSRNR1H4ALDH1A1LMNAGAA | |
| SCHEMBL4335252 | 0.82 | GHSR (0.50) | GHSRNR1H4ALDH1A1LMNAGAA | |
| SCHEMBL3638890 | 0.81 | GHSR (0.48) | GHSRNR1H4ALDH1A1LMNAGAA | |
| SCHEMBL4332286 | 0.81 | GHSR (0.47) | GHSRNR1H4ALDH1A1LMNAGAA | |
| SCHEMBL6081703 | 0.81 | GHSR (0.62) | GHSRALDH1A1LMNAGAAMAPT | |
| SCHEMBL1179572 | 0.80 | NR1H4 (0.67) | NR1H4PPARD | |
| SCHEMBL3640481 | 0.78 | NR1H4 (0.62) | NR1H4PPARDFABP1 | |
| SCHEMBL9535220 | 0.75 | GHSR (0.51) | GHSRALDH1A1LMNAGAAMAPT | |
| SCHEMBL12168917 | 0.75 | GHSR (0.45) | GHSRNR1H4ALDH1A1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173174-A1 | FARNESOID X RECEPTOR AGONISTS | GlaxoSmithKline LLC (US) | 2010-04-14 | — | — | EP | disclosed |
| WO-2009005998-A1 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-01-08 | — | — | WO | disclosed |