Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 20/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12170426 | 0.90 | GPR119 (0.66) | GPR119 | |
| SCHEMBL12170472 | 0.90 | GPR119 (0.56) | GPR119CYP2C9KCNH2 | |
| SCHEMBL12414061 | 0.89 | GPR119 (0.57) | GPR119CYP2C9KCNH2 | |
| SCHEMBL12170419 | 0.87 | GPR119 (0.66) | GPR119 | |
| SCHEMBL12170454 | 0.85 | GPR119 (0.59) | GPR119 | |
| SCHEMBL12170455 | 0.83 | GPR119 (0.69) | GPR119 | |
| SCHEMBL12170573 | 0.83 | GPR119 (0.45) | GPR119CYP2C9KCNH2 | |
| SCHEMBL12170481 | 0.83 | GPR119 (0.44) | GPR119CYP2C9KCNH2 | |
| SCHEMBL12170461 | 0.82 | GPR119 (0.54) | GPR119 | |
| SCHEMBL10108044 | 0.82 | GPR119 (0.75) | GPR119CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120232073-A1 | FUSED BICYCLIC PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF | MERCK SHARP & DOHME CORPORATION | 2012-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120232073-A1 | FUSED BICYCLIC PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF | GPR119, GCGR, GPR4 | GPR119 1/4885CYP2C9 1892/4885KCNH2 2973/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.