Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | UBE2M | P61081 | 2/20 | 0.37 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12176612 | 0.94 | NPSR1 (0.37) | CYP1A2CYP2C9RXFP1UBE2MDCUN1D1 | |
| SCHEMBL12176040 | 0.94 | CYP1A2 (0.36) | CYP1A2CYP2C9RXFP1UBE2MDCUN1D1 | |
| SCHEMBL21163759 | 0.94 | NPSR1 (0.37) | CYP1A2CYP2C9RXFP1UBE2MDCUN1D1 | |
| SCHEMBL13060049 | 0.94 | NPSR1 (0.37) | CYP1A2CYP2C9RXFP1UBE2MDCUN1D1 | |
| SCHEMBL13060010 | 0.94 | EPHX2 (0.37) | CYP1A2CYP2C9RXFP1UBE2MDCUN1D1 | |
| SCHEMBL12176567 | 0.93 | HSD17B10 (0.42) | CYP1A2CYP2C9RXFP1UBE2MDCUN1D1 | |
| SCHEMBL12176607 | 0.93 | HTR1A (0.38) | CYP1A2CYP2C9RXFP1UBE2MDCUN1D1 | |
| SCHEMBL12176320 | 0.92 | UBE2M (0.46) | RXFP1UBE2MDCUN1D1ALDH1A1MAPT | |
| SCHEMBL12176263 | 0.92 | RXFP1 (0.39) | CYP1A2CYP2C9RXFP1UBE2MDCUN1D1 | |
| SCHEMBL13059090 | 0.90 | RXFP1 (0.38) | CYP1A2CYP2C9RXFP1UBE2MDCUN1D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110275639-A1 | C5aR ANTAGONISTS | CHEMOCENTRYX, INC. (US) | 2011-11-10 | — | — | US | disclosed |
| US-20100311753-A1 | C5aR ANTAGONISTS | CHEMOCENTRYX, INC. (US) | 2010-12-09 | — | — | US | disclosed |
| US-20100160320-A1 | C5aR ANTAGONISTS | CHEMOCENTRYX, INC. (US) | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160320-A1 | C5aR ANTAGONISTS | C5AR1, C5AR2, C3AR1 | CYP1A2 2891/4885CYP2C9 2859/4885RXFP1 911/4885 |
| US-20110275639-A1 | C5aR ANTAGONISTS | C5AR1, C5AR2, C3AR1 | CYP1A2 2891/4885CYP2C9 2859/4885RXFP1 911/4885 |
| US-20100311753-A1 | C5aR ANTAGONISTS | C5AR1, C5AR2, C3AR1 | CYP1A2 2891/4885CYP2C9 2859/4885RXFP1 911/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.