Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12178707 | 0.76 | SMN1; SMN2 (0.32) | — | |
| SCHEMBL30479589 | 0.75 | OPRL1 (0.40) | OPRL1NR3C1 | |
| SCHEMBL12178738 | 0.74 | CHRNB2 (0.35) | — | |
| SCHEMBL12179332 | 0.73 | CHRNB2 (0.33) | — | |
| SCHEMBL12179327 | 0.73 | CHRM2 (0.38) | OPRL1 | |
| SCHEMBL2584526 | 0.72 | OPRL1 (0.40) | OPRL1NR3C1 | |
| SCHEMBL12179170 | 0.72 | OPRM1 (0.36) | OPRL1 | |
| SCHEMBL12178751 | 0.71 | CHRM2 (0.44) | — | |
| SCHEMBL15825000 | 0.70 | OPRL1 (0.39) | OPRL1 | |
| SCHEMBL12178857 | 0.70 | CHRNB2 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011135276-A1 | 3, 3 -DISUBSTITUTED- ( 8 - AZA - BICYCLO [3.2.1] OCT- 8 - YL) -[5- (1H - PYRAZOL - 4 -YL) -THIOPHEN-3 -YL] METHANONES AS INHIBITORS OF 11 (BETA) -HSD1 | THE UNIVERSITY OF EDINBURGH (GB) | 2011-11-03 | — | — | WO | disclosed |