Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | PNMT | P11086 | 4/20 | 0.41 |
| ▸ | TDP2 | O95551 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CTSD | P07339 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15025140 | 0.85 | NOTUM (0.44) | DPP7ALDH1A1AADATPNMTTDP2 | |
| SCHEMBL2056192 | 0.80 | DPP7 (0.47) | DPP7ALDH1A1TMEM97SIGMAR1PNMT | |
| SCHEMBL13923531 | 0.77 | DPP7 (0.45) | DPP7ALDH1A1TMEM97SIGMAR1PNMT | |
| SCHEMBL13939996 | 0.77 | DPP7 (0.51) | DPP7ALDH1A1TMEM97SIGMAR1PNMT | |
| SCHEMBL23745348 | 0.77 | DPP7 (0.48) | DPP7ALDH1A1TMEM97SIGMAR1PNMT | |
| SCHEMBL13938028 | 0.76 | TMEM97 (0.54) | DPP7ALDH1A1TMEM97SIGMAR1PNMT | |
| SCHEMBL13594616 | 0.74 | DPP7 (0.56) | DPP7ALDH1A1DPP4NAMPTNOTUM | |
| SCHEMBL23938535 | 0.73 | HTR2A (0.41) | ALDH1A1AADATPNMTNOTUM | |
| SCHEMBL20178647 | 0.73 | TMEM97 (0.52) | DPP7ALDH1A1TMEM97SIGMAR1PNMT | |
| SCHEMBL27974149 | 0.72 | TDP2 (0.49) | AADATPNMTTDP2PARP1PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2569298-B1 | NOVEL CCR2 RECEPTOR ANTAGONISTS, METHOD FOR PRODUCING THE SAME, AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM INT (DE) | 2015-11-25 | — | — | EP | disclosed |
| WO-2011141474-A1 | NOVEL CCR2 RECEPTOR ANTAGONISTS, METHOD FOR PRODUCING THE SAME, AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-11-17 | — | — | WO | disclosed |