Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ6 | P48051 | 6/20 | 0.42 |
| ▸ | KCNJ3 | P48549 | 6/20 | 0.42 |
| ▸ | KCNJ5 | P48544 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KHK | P50053 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.39 |
| ▸ | MARS1 | P56192 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2598511 | 0.82 | L3MBTL1 (0.51) | KCNJ6KCNJ3KCNJ5TP53NPC1 | |
| SCHEMBL31466032 | 0.77 | NPC1 (0.51) | KCNJ6KCNJ3KCNJ5TP53NPC1 | |
| SCHEMBL16827947 | 0.74 | TP53 (0.41) | KCNJ6KCNJ3KCNJ5TP53NPC1 | |
| Hydrochloric Acid SCHEMBL18169262 | 0.73 | SMN1; SMN2 (0.43) | KCNJ6KCNJ3KCNJ5TP53NPC1 | |
| SCHEMBL3093919 | 0.73 | KCNJ6 (0.50) | KCNJ6KCNJ3KCNJ5TP53NPC1 | |
| SCHEMBL2599117 | 0.69 | PRCP (0.56) | NPC1LMNARAB9ASMN1; SMN2KHK | |
| SCHEMBL3097657 | 0.69 | MAPT (0.42) | KCNJ6KCNJ3KCNJ5KHKMAPK1 | |
| SCHEMBL10395788 | 0.68 | KHK (0.54) | KHK | |
| SCHEMBL3100756 | 0.68 | CARM1 (0.44) | KCNJ6KCNJ3KCNJ5KHKKMT2A | |
| SCHEMBL28330785 | 0.68 | NPC1 (0.56) | KCNJ6KCNJ3KCNJ5TP53NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011143057-A1 | NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-11-17 | — | — | WO | disclosed |