Terodiline

Terodiline

SCHEMBL121864

CC(CC(c1ccccc1)c1ccccc1)NC(C)(C)C.Cl

nearest known ligand 0.96

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CHRM1CHRM2CHRM3CHRM4CHRM5

The experimentally established mechanism targets of Terodiline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 known ✓ P08172 2/20 0.96
CHRM1 known ✓ P11229 2/20 0.96
CACNA1C known ✓ Q13936 2/20 0.96
CACNA1F known ✓ O60840 1/20 0.96
CHRM3 known ✓ P20309 1/20 0.96
CACNA1D known ✓ Q01668 1/20 0.96
CACNA1S known ✓ Q13698 1/20 0.96
HRH1 P35367 4/20 0.96
ADRA1A P35348 3/20 0.96
SLC6A3 Q01959 3/20 0.96
KCNH2 Q12809 3/20 0.96
ADRA2B P18089 2/20 0.96
OPRK1 P41145 2/20 0.96
SCN5A Q14524 2/20 0.96
SLC6A4 P31645 3/20 0.50
CYP3A4 P08684 3/20 0.42
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
ALOX15 P16050 2/20 0.42
ALDH1A1 P00352 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Terodiline SCHEMBL78908 0.98 HRH1 (1.00) HRH1ADRA1ASLC6A3KCNH2CHRM2
Terodiline SCHEMBL9008621 0.98 HRH1 (1.00) HRH1ADRA1ASLC6A3KCNH2CHRM2
Terodiline SCHEMBL8149719 0.96 HRH1 (0.89) HRH1ADRA1ASLC6A3KCNH2CHRM2
Terodiline SCHEMBL579993 0.96 HRH1 (0.96) HRH1ADRA1ASLC6A3KCNH2CHRM2
Terodiline SCHEMBL110026 0.94 HRH1 (0.93) HRH1ADRA1ASLC6A3KCNH2CHRM2
SCHEMBL9008867 0.88 ADRA1A (0.81) HRH1ADRA1ASLC6A3KCNH2CHRM2
SCHEMBL9107533 0.88 ADRA1A (0.81) HRH1ADRA1ASLC6A3KCNH2CHRM2
SCHEMBL9008606 0.88 ADRA1A (0.81) HRH1ADRA1ASLC6A3KCNH2CHRM2
SCHEMBL9108716 0.88 ADRA1A (0.81) HRH1ADRA1ASLC6A3KCNH2CHRM2
SCHEMBL9008774 0.88 ADRA1A (0.81) HRH1ADRA1ASLC6A3KCNH2CHRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1324 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2001450-B1 DIRECTLY COMPRESSIBLE COMPOSITE FOR ORALLY DISINTEGRATING TABLETS RUBICON RES PRIVATE LIMITED (IN) 2019-01-30 EP claimed
CN-105550715-A Integrated classifier construction method based on neighbor propagation clustering UNIV DALIAN TECH 2016-05-04 CN claimed
CN-101460150-B Directly compressible compound for orally disintegrating tablets RUBICON RES PRIVATE LTD 2014-02-12 CN claimed
US-20090208576-A1 Orally Disintegrating Tablets RUBICON RESEARCH PRIVATE LIMITED (IN) 2009-08-20 US claimed
CN-101460150-A Directly compressible compound for orally disintegrating tablets RUBICON RES PRIVATE LTD (IN) 2009-06-17 CN claimed
EP-2001450-A2 DIRECTLY COMPRESSIBLE COMPOSITE FOR ORALLY DISINTEGRATING TABLETS Rubicon Research Private Limited (IN) 2008-12-17 EP claimed
EP-1915992-A1 USE OF CYCLOOXYGENASE INHIBITORS AND ANTIMUSCARINIC AGENTS FOR THE TREATMENT OF INCONTINENCE Pharmacia Corporation (US) 2008-04-30 EP claimed
WO-2007113856-A2 DIRECTLY COMPRESSIBLE COMPOSITE FOR ORALLY DISINTEGRATING TABLETS RUBICON RESEARCH PRIVATE LIMITED (IN) 2007-10-11 WO claimed
EP-1363668-B1 COMBINATIONS OF BILE ACID SEQUESTRANT(S) AND STEROL ABSORPTION INHIBITOR(S) AND TREATMENTS FOR VASCULAR INDICATIONS SCHERING CORP (US) 2007-08-15 EP claimed
WO-2007072503-A2 COMBINATIONS FOR MANAGING INFLAMMATION AND ASSOCIATED DISORDERS PANACEA BIOTEC LTD. (IN) 2007-06-28 WO claimed
EP-1273301-A2 Pharmaceutical preparations based on active ingredients susceptible to illicit administration ALTERGON S.A. (CH) 2003-01-08 EP claimed
WO-2002058731-A2 COMBINATIONS OF STEROL ABSORPTION INHIBITOR(S) WITH CARDIOVASCULAR AGENT(S) FOR THE TREATMENT OF VASCULAR CONDITIONS SCHERING CORPORATION (US) 2002-08-01 WO claimed
JP-2002520437-A 2002-07-09 JP claimed
CN-1315945-A Nitrate salts of antihypertensive drugs NICOX SA (FR) 2001-10-03 CN claimed
CN-1308650-A Method of coating pre-primed polyolefin films HOECHST TRESPAPHAN GMBH (DE) 2001-08-15 CN claimed
EP-1102806-A1 METHOD OF COATING PRE-PRIMED POLYOLEFIN FILMS Hoechst Trespaphan GmbH (DE) 2001-05-30 EP claimed
WO-2000002956-A1 METHOD OF COATING PRE-PRIMED POLYOLEFIN FILMS HOECHST TRESPAPHAN GMBH (DE) 2000-01-20 WO claimed
US-5700410-A Method of manufacturing wax matrices NIPPON SHINYAKU CO., LTD. (JP) 1997-12-23 US claimed
EP-0580860-B1 METHOD OF MANUFACTURING SOLID DISPERSION NIPPON SHINYAKU CO LTD (JP) 1997-10-22 EP claimed
US-5010671-A Flip chart pad DENNISON STATIONERY PRODUCTS COMPANY (US) 1991-04-30 US claimed