Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.71 |
| ▸ | RAB9A | P51151 | 3/20 | 0.71 |
| ▸ | MEN1 | O00255 | 5/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.71 |
| ▸ | MAPT | P10636 | 1/20 | 0.71 |
| ▸ | PKM | P14618 | 1/20 | 0.71 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.68 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.64 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.59 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.58 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.58 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.58 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.58 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.57 |
| ▸ | SMO | Q99835 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3645013 | 0.90 | MEN1 (0.74) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL12190100 | 0.88 | MEN1 (0.71) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL12190102 | 0.84 | KDM4E (0.72) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL4254150 | 0.83 | MEN1 (0.80) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL4254257 | 0.83 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL30369807 | 0.83 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL8768933 | 0.83 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL5344166 | 0.83 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL31432724 | 0.83 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL333237 | 0.83 | SRD5A2 (0.78) | NPC1RAB9AMEN1KMT2ASRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150031663-A1 | PHTHALANILATE COMPOUNDS AND METHODS OF USE | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2015-01-29 | — | — | US | disclosed |
| US-8859620-B2 | Phthalanilate compounds and methods of use | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2014-10-14 | — | — | US | disclosed |
| US-20120232150-A1 | PHTHALANILATE COMPOUNDS AND METHODS OF USE | University of Nortre Dame du Lac | 2012-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120232150-A1 | PHTHALANILATE COMPOUNDS AND METHODS OF USE | MPO, ALPI, NQO1 | NPC1 2813/4885RAB9A 3788/4885MEN1 2365/4885 |
| US-20150031663-A1 | PHTHALANILATE COMPOUNDS AND METHODS OF USE | MPO, ALPI, NQO1 | NPC1 2813/4885RAB9A 3788/4885MEN1 2365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.