Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 4/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 8/20 | 0.53 |
| ▸ | JAK1 | P23458 | 5/20 | 0.53 |
| ▸ | PLK4 | O00444 | 2/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.50 |
| ▸ | JAK3 | P52333 | 5/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL374117 | 0.83 | CD274 (0.57) | MAPK10MAPK9LCKJAK2JAK1 | |
| SCHEMBL374409 | 0.80 | CD274 (0.59) | MAPK10LCKJAK2JAK1JAK3 | |
| SCHEMBL2194198 | 0.77 | JAK2 (0.56) | MAPK10LCKJAK2JAK1JAK3 | |
| SCHEMBL27681354 | 0.77 | JAK1 (0.53) | MAPK10MAPK9LCKJAK2JAK1 | |
| SCHEMBL28290063 | 0.76 | JAK2 (0.67) | JAK2JAK1PLK4JAK3 | |
| SCHEMBL2178686 | 0.75 | JAK3 (0.63) | MAPK10JAK2JAK1JAK3CD274 | |
| SCHEMBL12482572 | 0.75 | JAK2 (0.62) | MAPK10JAK2JAK1JAK3CD274 | |
| SCHEMBL13300755 | 0.74 | CCNA2 (0.77) | MAPK10MAPK9AURKAAURKBIGF1R | |
| SCHEMBL12482797 | 0.74 | JAK2 (0.53) | MAPK10JAK2JAK1AURKAAURKB | |
| SCHEMBL8799812 | 0.74 | JAK2 (0.53) | MAPK10LCKJAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899329-B1 | PYRIMIDINE-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2011-10-05 | — | — | EP | disclosed |