Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 6/20 | 0.64 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 9/20 | 0.53 |
| ▸ | CHUK | O15111 | 6/20 | 0.53 |
| ▸ | LCK | P06239 | 2/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.45 |
| ▸ | PRKACA | P17612 | 2/20 | 0.45 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.45 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.45 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.45 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.45 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.45 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.45 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.45 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.45 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 2/20 | 0.43 |
| ▸ | PIM1 | P11309 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12192871 | 0.85 | ROCK1 (0.68) | IKBKBPRKCZROCK1CHUKROCK2 | |
| SCHEMBL12193213 | 0.84 | IKBKB (0.64) | IKBKBPRKCZROCK1CHUKLCK | |
| SCHEMBL12192879 | 0.84 | IKBKB (0.64) | IKBKBPRKCZROCK1CHUKLCK | |
| Hydrochloric Acid SCHEMBL2497446 | 0.83 | IKBKB (0.62) | IKBKBPRKCZROCK1CHUKLCK | |
| SCHEMBL12192872 | 0.81 | IKBKB (0.52) | IKBKBPRKCZCHUKPIM1 | |
| SCHEMBL12192867 | 0.79 | IKBKB (0.91) | IKBKBPRKCZROCK1CHUKLCK | |
| Hydrochloric Acid SCHEMBL2496034 | 0.78 | IKBKB (0.89) | IKBKBPRKCZROCK1CHUKLCK | |
| Hydrochloric Acid SCHEMBL29863202 | 0.78 | IKBKB (0.89) | IKBKBPRKCZROCK1CHUKLCK | |
| SCHEMBL12192875 | 0.77 | IKBKB (0.72) | IKBKBPRKCZROCK1CHUKLCK | |
| Hydrochloric Acid SCHEMBL23360340 | 0.77 | IKBKB (0.97) | IKBKBPRKCZROCK1CHUKLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8722671-B2 | Isoquinoline derivatives | SANOFI (FR) | 2014-05-13 | — | — | US | disclosed |
| US-8722671-B2 | Isoquinoline derivatives | SANOFI (FR) | 2014-05-13 | — | — | US | disclosed |
| US-8501736-B2 | Isoquinoline derivatives | SANOFI (FR) | 2013-08-06 | — | — | US | disclosed |
| US-8501736-B2 | Isoquinoline derivatives | SANOFI (FR) | 2013-08-06 | — | — | US | disclosed |
| US-20110245248-A1 | ISOQUINOLINE DERIVATIVES | SANOFI-AVENTIS (FR) | 2011-10-06 | — | — | US | disclosed |
| US-20110245248-A1 | ISOQUINOLINE DERIVATIVES | SANOFI-AVENTIS (FR) | 2011-10-06 | — | — | US | disclosed |
| US-20090088429-A1 | Isoquinoline Derivatives | SANOFI-AVENTIS (FR) | 2009-04-02 | — | — | US | disclosed |
| US-20090088429-A1 | Isoquinoline Derivatives | SANOFI-AVENTIS (FR) | 2009-04-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110245248-A1 | ISOQUINOLINE DERIVATIVES | MYLK2, MYLK, RHOT2 | IKBKB 866/4885PRKCZ 74/4885ROCK1 7/4885 |
| US-20090088429-A1 | Isoquinoline Derivatives | MYLK2, MYLK, RHOT2 | IKBKB 866/4885PRKCZ 74/4885ROCK1 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.