Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14078197 | 0.83 | — | — | |
| SCHEMBL8242669 | 0.81 | BCHE (0.35) | SMN1; SMN2 | |
| SCHEMBL2535091 | 0.79 | SMN1; SMN2 (0.37) | SMN1; SMN2MAPTTP53 | |
| SCHEMBL31623264 | 0.78 | HSD11B1 (0.33) | — | |
| SCHEMBL428708 | 0.78 | — | — | |
| SCHEMBL12050687 | 0.77 | SMN1; SMN2 (0.33) | SMN1; SMN2MAPTTP53 | |
| SCHEMBL12193850 | 0.77 | GAA (0.41) | SMN1; SMN2MAPTTP53 | |
| SCHEMBL13768199 | 0.77 | SMN1; SMN2 (0.36) | SMN1; SMN2TP53 | |
| SCHEMBL2213404 | 0.76 | MAPT (0.38) | SMN1; SMN2MAPT | |
| SCHEMBL190770 | 0.76 | KDM4E (0.38) | SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966151-B1 | POLYCYCLIC INDAZOLE DERIVATIVES THAT ARE ERK INHIBITORS | SCHERING CORP (US) | 2011-10-05 | — | — | EP | disclosed |
| WO-2008156739-A1 | HETEROCYCLIC COMPOUNDS AND USE THEREOF AS ERK INHIBITORS | SCHERING CORPORATION (US) | 2008-12-24 | — | — | WO | disclosed |