Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | CASP1 | P29466 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.45 |
| ▸ | FEN1 | P39748 | 1/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16738481 | 0.80 | HSP90AA1 (0.41) | TSHRCASP1SMN1; SMN2HPGDNR1H4 | |
| Hydrochloric Acid SCHEMBL6900887 | 0.79 | TSHR (0.58) | TSHRCASP1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL20832360 | 0.79 | MEN1 (0.47) | TSHRCASP1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL12532565 | 0.77 | SMN1; SMN2 (0.59) | TSHRCASP1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL16738521 | 0.74 | ALDH1A1 (0.34) | ALDH1A1POLBRECQLTDP1L3MBTL1 | |
| SCHEMBL14034212 | 0.73 | PARP1 (0.49) | SMN1; SMN2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL11231466 | 0.72 | ALDH1A1 (0.69) | TSHRCASP1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL11231463 | 0.72 | ALDH1A1 (0.69) | TSHRCASP1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL2461313 | 0.72 | SMN1; SMN2 (0.53) | TSHRCASP1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL107060 | 0.72 | SMN1; SMN2 (0.68) | TSHRCASP1SMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7893096-B2 | For example, N-methyl-4-[(2-{[2-(1-methylethyl)phenyl]amino}-1 H-benzimidazol-5-yl)oxy]pyridine-2-carboxamide; administering the compounds alone or in combination with another agent for the treatment of cancer, infectious diseases and/or allergies/asthma | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2011-02-22 | — | — | US | disclosed |