Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 17/20 | 0.80 |
| ▸ | PDE2A | O00408 | 2/20 | 0.73 |
| ▸ | PDE8A | O60658 | 2/20 | 0.73 |
| ▸ | PDE5A | O76074 | 2/20 | 0.73 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.73 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.73 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.73 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.73 |
| ▸ | PDE9A | O76083 | 1/20 | 0.73 |
| ▸ | PDE1A | P54750 | 2/20 | 0.65 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12198193 | 0.89 | PDE4A (0.85) | PDE4APDE2APDE8APDE5APDE3B | |
| SCHEMBL18927849 | 0.89 | PDE4A (1.00) | PDE4APDE2APDE8APDE5APDE3B | |
| SCHEMBL2507601 | 0.89 | PDE4A (1.00) | PDE4APDE2APDE8APDE5APDE3B | |
| SCHEMBL12198227 | 0.85 | PDE4A (0.69) | PDE4APDE2APDE8APDE5APDE3B | |
| SCHEMBL12198180 | 0.85 | PDE4A (0.73) | PDE4APDE2APDE8APDE5APDE3B | |
| SCHEMBL15255675 | 0.85 | PDE4A (0.73) | PDE4APDE2APDE8APDE5APDE3B | |
| SCHEMBL12198217 | 0.85 | PDE4A (0.82) | PDE4APDE1APDE1B | |
| SCHEMBL2412384 | 0.84 | PDE4A (0.58) | PDE4APDE2APDE8APDE5APDE3B | |
| SCHEMBL772857 | 0.84 | PDE4A (1.00) | PDE4APDE2APDE8APDE5APDE3B | |
| SCHEMBL16899893 | 0.84 | PDE4A (1.00) | PDE4APDE2APDE8APDE5APDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160083390-A1 | ORGANIC COMPOUNDS | LI PENG (US) | 2016-03-24 | — | — | US | disclosed |
| US-20160083390-A1 | ORGANIC COMPOUNDS | LI PENG (US) | 2016-03-24 | — | — | US | disclosed |
| US-20150038474-A1 | ORGANIC COMPOUNDS | LI PENG (US) | 2015-02-05 | — | — | US | disclosed |
| US-20150038474-A1 | ORGANIC COMPOUNDS | LI PENG (US) | 2015-02-05 | — | — | US | disclosed |
| US-8536159-B2 | Organic compounds | INTRA-CELLULAR THERAPIES, INC. (US) | 2013-09-17 | — | — | US | disclosed |
| US-8536159-B2 | Organic compounds | INTRA-CELLULAR THERAPIES, INC. (US) | 2013-09-17 | — | — | US | disclosed |
| US-20110245214-A1 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC. | 2011-10-06 | — | — | US | disclosed |
| US-20110245214-A1 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC. | 2011-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150038474-A1 | ORGANIC COMPOUNDS | TPMT, SULT1E1, UGT2B7 | PDE4A 2122/4885PDE2A 2425/4885PDE8A 2494/4885 |
| US-20160083390-A1 | ORGANIC COMPOUNDS | TPMT, SULT1E1, UGT2B7 | PDE4A 2122/4885PDE2A 2425/4885PDE8A 2494/4885 |
| US-20110245214-A1 | ORGANIC COMPOUNDS | CYP3A7, TPMT, UGT2B7 | PDE4A 2270/4885PDE2A 2486/4885PDE8A 2382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.