Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ESRRB | O95718 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.31 |
| ▸ | TAB1 | Q15750 | 2/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.31 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10276525 | 1.00 | ALDH1A1 (0.35) | ALDH1A1SMN1; SMN2THRBCYP2C9CYP2C19 | |
| SCHEMBL21782663 | 0.86 | MEN1 (0.33) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL21266611 | 0.85 | CYP1A2 (0.37) | CYP2C9ESR1ESR2 | |
| SCHEMBL23048409 | 0.85 | NLRP3 (0.32) | ALDH1A1MAP3K7TAB1 | |
| SCHEMBL16452416 | 0.84 | SMN1; SMN2 (0.31) | ALDH1A1SMN1; SMN2MAP3K7TAB1 | |
| SCHEMBL16452417 | 0.84 | SMN1; SMN2 (0.31) | ALDH1A1SMN1; SMN2MAP3K7TAB1 | |
| SCHEMBL833709 | 0.84 | ALDH1A1 (0.36) | ALDH1A1MAP3K7TAB1 | |
| SCHEMBL8365459 | 0.84 | ESR1 (0.33) | ESR1ESR2 | |
| SCHEMBL262238 | 0.84 | ALDH1A1 (0.36) | ALDH1A1MAP3K7TAB1 | |
| SCHEMBL29103272 | 0.84 | HDAC6 (0.36) | ALDH1A1THRBCYP2C9CYP2C19HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2371421-A1 | Ligands of insulin degrading enzyme and their uses | Université de Lille 2 Droit et Santé (FR) | 2011-10-05 | — | — | EP | disclosed |
| WO-2011107948-A2 | LIGANDS OF INSULIN DEGRADING ENZYME AND THEIR USES | UNIVERSITE LILLE 2 DROIT ET SANTE (FR) | 2011-09-09 | — | — | WO | disclosed |