Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | KHK | P50053 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | TRIM58 | Q8NG06 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12205189 | 0.86 | CRHR1 (0.39) | CHEK1CHEK2ROCK2ROCK1CDC42BPB | |
| SCHEMBL4925453 | 0.84 | ROCK2 (0.45) | ROCK2ROCK1CDC42BPBHRH4PIM2 | |
| SCHEMBL12205243 | 0.82 | CHRNB4 (0.48) | CHEK1PIM1 | |
| SCHEMBL12531359 | 0.80 | KDM1A (0.50) | ROCK2ROCK1CDC42BPBPIM1PRKCQ | |
| SCHEMBL12205338 | 0.80 | SYK (0.42) | CHEK2ROCK2ROCK1CDC42BPBPIM2 | |
| SCHEMBL12205340 | 0.79 | APP (0.46) | CHEK1CHEK2ROCK2ROCK1CDC42BPB | |
| SCHEMBL12205225 | 0.79 | APP (0.51) | CHEK1PIM1 | |
| SCHEMBL5349891 | 0.79 | CYP2D6 (0.44) | ROCK2ROCK1CDC42BPBHRH4PIM1 | |
| Hydrochloric Acid SCHEMBL6149753 | 0.77 | CYP2D6 (0.43) | ROCK2ROCK1CDC42BPBHRH4PIM1 | |
| Hydrochloric Acid SCHEMBL5395261 | 0.77 | CYP2D6 (0.43) | ROCK2ROCK1CDC42BPBHRH4PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110256064-A1 | Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-like Proteins | AC IMMUNE, S.A. (CH) | 2011-10-20 | — | — | US | disclosed |
| EP-2377860-A1 | Novel compounds for the treatment of diseases associated with amyloid or amyloid-like proteins | AC Immune S.A. (CH) | 2011-10-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110256064-A1 | Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-like Proteins | APP, PSEN1, PSEN2 | CHEK1 4284/4885CHEK2 4532/4885ROCK2 1309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.