Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 10/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2480752 | 0.88 | PTGDR2 (0.51) | PTGDR2AKR1B1 | |
| SCHEMBL11959139 | 0.76 | PTGDR2 (0.54) | PTGDR2AKR1B1 | |
| SCHEMBL11959133 | 0.75 | PTGDR2 (0.48) | PTGDR2 | |
| SCHEMBL4394762 | 0.70 | PTGDR2 (0.67) | PTGDR2 | |
| SCHEMBL4958492 | 0.69 | PTGDR2 (0.46) | PTGDR2 | |
| SCHEMBL11959132 | 0.69 | PTGDR2 (0.44) | PTGDR2OPRL1 | |
| SCHEMBL2483141 | 0.69 | PTGDR2 (0.75) | PTGDR2 | |
| SCHEMBL5007572 | 0.67 | ALDH1A1 (0.46) | OPRL1 | |
| SCHEMBL14876503 | 0.67 | CASP1 (0.52) | — | |
| SCHEMBL22040148 | 0.66 | NR1H2 (0.35) | NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891075-B1 | TRICYCLIC SPIRO DERIVATIVES AS CRTH2 MODULATORS | MERCK SERONO SA (CH) | 2011-10-19 | — | — | EP | disclosed |