Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 8/20 | 0.67 |
| ▸ | KCNK9 | Q9NPC2 | 7/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 3/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | PGR | P06401 | 1/20 | 0.60 |
| ▸ | AR | P10275 | 1/20 | 0.60 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.59 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.59 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14363190 | 0.90 | KCNK3 (0.68) | KCNK3KCNK9KCNH2KDM4EMAPT | |
| SCHEMBL28922759 | 0.87 | RAB9A (0.66) | KCNK3KCNK9KDM4EMAPTMEN1 | |
| SCHEMBL14301092 | 0.86 | SMN1; SMN2 (0.75) | KCNK3KCNK9KCNH2KDM4EMAPT | |
| SCHEMBL15006333 | 0.84 | KCNK3 (0.76) | KCNK3KCNK9KCNH2KDM4EMAPT | |
| SCHEMBL20083957 | 0.84 | KCNK3 (0.64) | KCNK3KCNK9KCNH2KDM4EMAPT | |
| SCHEMBL4258402 | 0.84 | KCNK3 (0.64) | KCNK3KCNK9KCNH2KDM4EMAPT | |
| SCHEMBL23677196 | 0.82 | STAT3 (0.58) | MEN1KMT2ANPC1RAB9APGR | |
| SCHEMBL14363225 | 0.82 | POLB (0.75) | KCNK3KCNK9KCNH2MEN1KMT2A | |
| SCHEMBL17831484 | 0.81 | KCNK3 (0.71) | KCNK3KCNK9KCNH2KDM4EMAPT | |
| SCHEMBL4248125 | 0.81 | KCNK3 (0.82) | KCNK3KCNK9KCNH2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8034940-B2 | Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-10-11 | — | — | US | disclosed |
| US-20090075995-A1 | MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF | BRISTOL-MYERS SQUIBB COMPANY | 2009-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090075995-A1 | MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF | NFKB2, NFRKB, NFKB1 | KCNK3 1115/4885KCNK9 793/4885KCNH2 2983/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.