Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TLR2 | O60603 | 2/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8054566 | 0.91 | HTR2C (0.50) | HTR2CNPC1RAB9AKMOPOLB | |
| SCHEMBL12209608 | 0.87 | SLC6A4 (0.48) | HTR2CKMOHCRTR1HCRTR2 | |
| SCHEMBL8061928 | 0.85 | LIMK2 (0.43) | HTR2CNPC1RAB9ATGFBR1ALDH1A1 | |
| SCHEMBL12209643 | 0.85 | HTR2C (0.44) | HTR2CKMOPOLBKDM4EALDH1A1 | |
| SCHEMBL19280163 | 0.77 | NPC1 (0.49) | NPC1RAB9ATGFBR1POLBKDM4E | |
| SCHEMBL13609464 | 0.76 | HCRTR1 (0.56) | HTR2CTLR2HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL30804747 | 0.76 | TGFBR1 (0.49) | NPC1RAB9ATGFBR1HPGDTSHR | |
| SCHEMBL373768 | 0.75 | LIMK2 (0.47) | HTR2CNPC1RAB9APOLBALDH1A1 | |
| Hydrochloric Acid SCHEMBL4303987 | 0.75 | HCRTR1 (0.55) | HTR2CTLR2HCRTR1HCRTR2HPGD | |
| SCHEMBL12577717 | 0.75 | HTR2C (0.58) | HTR2CKMOTLR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2610258-A1 | Substituted piperidino dihydrothieno pyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-07-03 | — | — | EP | disclosed |
| EP-2380891-A1 | Substituted piperidino-dihydrothienopyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-10-26 | — | — | EP | disclosed |