Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24306734 | 0.81 | NPC1 (0.32) | HSD11B1NPC1 | |
| SCHEMBL5946341 | 0.80 | SYK (0.39) | NPC1 | |
| SCHEMBL24306817 | 0.78 | HSD11B1 (0.31) | HSD11B1 | |
| SCHEMBL12235337 | 0.78 | KCNH2 (0.32) | NPC1 | |
| SCHEMBL24306818 | 0.75 | NPC1 (0.35) | CRBNNPC1 | |
| SCHEMBL24306815 | 0.74 | CRBN (0.36) | CRBNNPC1 | |
| SCHEMBL13657938 | 0.71 | BRD4 (0.33) | CRBNHSD11B1 | |
| SCHEMBL12212772 | 0.71 | NR3C2 (0.47) | NPC1 | |
| SCHEMBL24306751 | 0.68 | MMP12 (0.50) | NPC1 | |
| SCHEMBL17026912 | 0.68 | BRD4 (0.34) | HSD11B1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110251177-A1 | 2, 4-PYRIMIDINEDIAMINE COMPOUNDS AND PRODRUGS THEREOF AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2011-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110251177-A1 | 2, 4-PYRIMIDINEDIAMINE COMPOUNDS AND PRODRUGS THEREOF AND THEIR USES | TYMP, DPYD, TYMS | CRBN 4614/4885HSD11B1 3981/4885NPC1 2396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.