Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 14/20 | 0.45 |
| ▸ | AURKA | O14965 | 6/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.45 |
| ▸ | PLK4 | O00444 | 3/20 | 0.45 |
| ▸ | FLT3 | P36888 | 3/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.45 |
| ▸ | JAK2 | O60674 | 3/20 | 0.45 |
| ▸ | LCK | P06239 | 3/20 | 0.45 |
| ▸ | LYN | P07948 | 3/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.45 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.45 |
| ▸ | STK16 | O75716 | 2/20 | 0.45 |
| ▸ | RET | P07949 | 2/20 | 0.45 |
| ▸ | MST1R | Q04912 | 2/20 | 0.45 |
| ▸ | TNK1 | Q13470 | 2/20 | 0.45 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.45 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17277998 | 0.89 | SYK (0.47) | SYKAURKAMAPK8PLK4FLT3 | |
| SCHEMBL12237028 | 0.86 | SYK (0.45) | SYKAURKAMAPK8PLK4FLT3 | |
| SCHEMBL12212789 | 0.82 | SYK (0.59) | SYKAURKAMAPK8PLK4FLT3 | |
| SCHEMBL12212798 | 0.82 | SYK (0.49) | SYKAURKAJAK2LCKLYN | |
| SCHEMBL12212784 | 0.81 | SYK (0.66) | SYKAURKAMAPK8PLK4FLT3 | |
| SCHEMBL12212787 | 0.78 | SYK (0.51) | SYKAURKAMAPK8PLK4FLT3 | |
| SCHEMBL12212782 | 0.73 | SYK (0.54) | SYKAURKAMAPK8PLK4FLT3 | |
| SCHEMBL2103803 | 0.71 | SYK (0.55) | SYKAURKAJAK2LCKLYN | |
| SCHEMBL15397375 | 0.71 | SYK (0.63) | SYKAURKAMAPK8PLK4FLT3 | |
| SCHEMBL17278002 | 0.70 | MAOB (0.50) | SYKAURKAJAK2LCKLYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110251177-A1 | 2, 4-PYRIMIDINEDIAMINE COMPOUNDS AND PRODRUGS THEREOF AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2011-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110251177-A1 | 2, 4-PYRIMIDINEDIAMINE COMPOUNDS AND PRODRUGS THEREOF AND THEIR USES | TYMP, DPYD, TYMS | SYK 1871/4885AURKA 629/4885MAPK8 1896/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.