Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 15/20 | 0.47 |
| ▸ | AURKA | O14965 | 6/20 | 0.47 |
| ▸ | JAK2 | O60674 | 3/20 | 0.47 |
| ▸ | LCK | P06239 | 3/20 | 0.47 |
| ▸ | LYN | P07948 | 3/20 | 0.47 |
| ▸ | PLK4 | O00444 | 3/20 | 0.47 |
| ▸ | FLT3 | P36888 | 3/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.47 |
| ▸ | KDR | P35968 | 3/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.47 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.47 |
| ▸ | STK16 | O75716 | 2/20 | 0.47 |
| ▸ | RET | P07949 | 2/20 | 0.47 |
| ▸ | MST1R | Q04912 | 2/20 | 0.47 |
| ▸ | TNK1 | Q13470 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12212792 | 0.89 | SYK (0.45) | SYKAURKAJAK2LCKLYN | |
| SCHEMBL12237028 | 0.89 | SYK (0.45) | SYKAURKAJAK2LCKLYN | |
| SCHEMBL17278002 | 0.80 | MAOB (0.50) | SYKAURKAJAK2LCKLYN | |
| SCHEMBL12854262 | 0.80 | SYK (0.69) | SYKAURKAJAK2LCKLYN | |
| SCHEMBL15397375 | 0.80 | SYK (0.63) | SYKAURKAJAK2LCKLYN | |
| SCHEMBL2103803 | 0.74 | SYK (0.55) | SYKAURKAJAK2LCKLYN | |
| SCHEMBL12854264 | 0.73 | SYK (0.44) | SYKAURKAJAK2LCKLYN | |
| SCHEMBL22068257 | 0.72 | SYK (0.69) | SYKAURKAJAK2LCKLYN | |
| SCHEMBL12212789 | 0.70 | SYK (0.59) | SYKAURKAJAK2LCKLYN | |
| SCHEMBL12212798 | 0.70 | SYK (0.49) | SYKAURKAJAK2LCKLYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558474-B1 | 2, 4-PYRIMIDINEDIAMINE COMPOUNDS AND PRODRUGS THEREOF AND THEIR USES | RIGEL PHARMACEUTICALS INC (US) | 2015-11-25 | — | — | EP | disclosed |