Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 6/20 | 0.75 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.75 |
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.68 |
| ▸ | MEN1 | O00255 | 3/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.68 |
| ▸ | CISD1 | Q9NZ45 | 3/20 | 0.64 |
| ▸ | PIM1 | P11309 | 1/20 | 0.62 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.62 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.62 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | NAT1 | P18440 | 1/20 | 0.60 |
| ▸ | MGAM | O43451 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8311580 | 0.87 | PDE4B (1.00) | PDE4BPDE3AADAMTS5MEN1KMT2A | |
| SCHEMBL8311581 | 0.87 | PDE4B (1.00) | PDE4BPDE3AADAMTS5MEN1KMT2A | |
| SCHEMBL7066328 | 0.86 | HPGD (0.67) | ADAMTS5MEN1KMT2ACISD1IGF1R | |
| SCHEMBL7066323 | 0.86 | HPGD (0.67) | ADAMTS5MEN1KMT2ACISD1IGF1R | |
| SCHEMBL7958251 | 0.83 | MMP13 (0.70) | ADAMTS5CISD1NAT1 | |
| SCHEMBL7958249 | 0.83 | MMP13 (0.70) | ADAMTS5CISD1NAT1 | |
| SCHEMBL8310975 | 0.81 | PDE4B (0.89) | PDE4BPDE3AADAMTS5MEN1KMT2A | |
| SCHEMBL8306525 | 0.81 | PDE4B (0.89) | PDE4BPDE3AADAMTS5MEN1KMT2A | |
| SCHEMBL8310978 | 0.81 | PDE4B (0.89) | PDE4BPDE3AADAMTS5MEN1KMT2A | |
| SCHEMBL8306523 | 0.81 | PDE4B (0.89) | PDE4BPDE3AADAMTS5MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110257146-A1 | Method of Treating Kcnq Related Disorders Using Organozinc Compounds | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-10-20 | — | — | US | disclosed |
| US-20110257146-A1 | Method of Treating Kcnq Related Disorders Using Organozinc Compounds | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-10-20 | — | — | US | disclosed |
| WO-2007087424-A2 | METHOD OF TREATING KCNQ RELATED DISORDERS USING ORGANOZINC COMPOUNDS | THE JOHNS HOPKINS UNIVERSITY (US) | 2007-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110257146-A1 | Method of Treating Kcnq Related Disorders Using Organozinc Compounds | KCNQ3, KCNQ1, KCNQ5 | PDE4B 1707/4885PDE3A 589/4885ADAMTS5 1771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.