Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 14/20 | 0.68 |
| ▸ | PIK3CG | P48736 | 10/20 | 0.68 |
| ▸ | PIK3R1 | P27986 | 9/20 | 0.68 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.68 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.51 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12263414 | 0.89 | PIK3CD (0.68) | PIK3CDPIK3CGPIK3R1PIK3CBPIK3CA | |
| SCHEMBL2548473 | 0.82 | PIK3CD (0.64) | PIK3CDPIK3CGPIK3R1PIK3CBPIK3CA | |
| SCHEMBL2505314 | 0.81 | PIK3CD (1.00) | PIK3CDPIK3CGPIK3R1PIK3CBPIK3CA | |
| SCHEMBL2511207 | 0.71 | PIK3CD (1.00) | PIK3CDPIK3CGPIK3R1PIK3CBPIK3CA | |
| SCHEMBL2508335 | 0.71 | PIK3CD (1.00) | PIK3CDPIK3CGPIK3R1PIK3CBPIK3CA | |
| SCHEMBL2505115 | 0.70 | PIK3CD (1.00) | PIK3CDPIK3CGPIK3R1PIK3CBPIK3CA | |
| SCHEMBL2508106 | 0.70 | PIK3CD (1.00) | PIK3CDPIK3CGPIK3R1PIK3CBPIK3CA | |
| SCHEMBL19006284 | 0.70 | PIK3CD (0.55) | PIK3CDPIK3CGPIK3R1PIK3CBPIK3CA | |
| SCHEMBL2507074 | 0.69 | PIK3CD (1.00) | PIK3CDPIK3CGPIK3R1PIK3CBPIK3CA | |
| SCHEMBL2508285 | 0.69 | PIK3CD (0.41) | PIK3CDPIK3CGPIK3R1PIK3CBPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110245257-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2011-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110245257-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | MCL1, BCL9, MALT1 | PIK3CD 16/4885PIK3CG 54/4885PIK3R1 48/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.