Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 17/20 | 0.68 |
| ▸ | PIK3R1 | P27986 | 9/20 | 0.68 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.68 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.68 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12221791 | 0.89 | PIK3CD (0.68) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL2505115 | 0.81 | PIK3CD (1.00) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL2508106 | 0.81 | PIK3CD (1.00) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL2548473 | 0.78 | PIK3CD (0.64) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL2508310 | 0.71 | PIK3CD (1.00) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL2505314 | 0.70 | PIK3CD (1.00) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL2507074 | 0.69 | PIK3CD (1.00) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL19006284 | 0.68 | PIK3CD (0.55) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL2505273 | 0.68 | PIK3CD (0.88) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL2511207 | 0.67 | PIK3CD (1.00) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123751-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2011-10-06 | — | — | WO | disclosed |