Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 20/20 | 0.64 |
| ▸ | PIK3CB | P42338 | 13/20 | 0.64 |
| ▸ | PIK3CG | P48736 | 13/20 | 0.64 |
| ▸ | PIK3R1 | P27986 | 8/20 | 0.64 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12221791 | 0.82 | PIK3CD (0.68) | PIK3CDPIK3CBPIK3CGPIK3R1PIK3CA | |
| SCHEMBL12263414 | 0.78 | PIK3CD (0.68) | PIK3CDPIK3CBPIK3CGPIK3R1PIK3CA | |
| SCHEMBL2508335 | 0.78 | PIK3CD (1.00) | PIK3CDPIK3CBPIK3CGPIK3R1PIK3CA | |
| SCHEMBL2511207 | 0.78 | PIK3CD (1.00) | PIK3CDPIK3CBPIK3CGPIK3R1PIK3CA | |
| SCHEMBL2549027 | 0.76 | PIK3CD (0.44) | PIK3CDPIK3CBPIK3CGPIK3R1PIK3CA | |
| SCHEMBL2719384 | 0.76 | PIK3CD (0.64) | PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL2717151 | 0.75 | PIK3CD (0.57) | PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL17397151 | 0.75 | PIK3CD (0.54) | PIK3CDPIK3CBPIK3CGPIK3R1PIK3CA | |
| SCHEMBL18989205 | 0.75 | PIK3CD (0.67) | PIK3CDPIK3CBPIK3CGPIK3R1PIK3CA | |
| SCHEMBL18988492 | 0.74 | PIK3CD (0.59) | PIK3CDPIK3CBPIK3CGPIK3R1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552908-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2013-02-06 | — | — | EP | disclosed |
| WO-2011123751-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2011-10-06 | — | — | WO | disclosed |