SCHEMBL1222451

SCHEMBL1222451

CCCn1c(=O)c2[nH]c(-c3cc(OCC(=O)Nc4ccc5c(c4)OCO5)nn3C)nc2n(CCC)c1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ ADORA2B P29275 20/20 1.00
▸ ADORA1 P30542 11/20 1.00
▸ ADORA2A P29274 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14517874 0.90 ADORA2B (0.82) ADORA2BADORA1ADORA2A
SCHEMBL1779353 0.89 ADORA2B (0.80) ADORA2BADORA1ADORA2A
SCHEMBL1780170 0.87 ADORA2B (1.00) ADORA2BADORA1ADORA2A
SCHEMBL29742673 0.87 ADORA2B (1.00) ADORA2BADORA1ADORA2A
SCHEMBL1780530 0.87 ADORA2B (1.00) ADORA2BADORA1ADORA2A
SCHEMBL1780185 0.87 ADORA2B (1.00) ADORA2BADORA1ADORA2A
SCHEMBL5331775 0.86 ADORA2B (1.00) ADORA2BADORA1ADORA2A
SCHEMBL29352331 0.86 ADORA2B (1.00) ADORA2BADORA1ADORA2A
SCHEMBL14267728 0.86 ADORA2B (1.00) ADORA2BADORA1ADORA2A
SCHEMBL14267696 0.86 ADORA2B (1.00) ADORA2BADORA1ADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240219394-A1 METHOD FOR MEASURING RESPONSE OF OLFACTORY RECEPTOR TO SUBSTANCE AJINOMOTO CO., INC. (JP) 2024-07-04 — — US claimed
EP-4382612-A1 METHOD FOR MEASURING RESPONSE OF OLFACTORY RECEPTOR TO SUBSTANCE AJINOMOTO CO., INC. (JP) 2024-06-12 — — EP claimed
CN-117321080-A Combination therapy using anti-CD 38 antibodies and PARP or adenosine receptor inhibitors 詹森生物科技公司 2023-12-29 — — CN claimed
EP-4294844-A1 COMBINATION THERAPIES WITH ANTI-CD38 ANTIBODIES AND PARP OR ADENOSINE RECEPTOR INHIBITORS Janssen Biotech, Inc. (US) 2023-12-27 — — EP claimed
WO-2023013791-A1 METHOD FOR MEASURING RESPONSE OF OLFACTORY RECEPTOR TO SUBSTANCE 味の素株式会社 2023-02-09 — — WO claimed
US-20220275090-A1 Combination Therapies with Anti-CD38 Antibodies and PARP or Adenosine Receptor Inhibitors JANSSEN BIOTECH, INC. 2022-09-01 — — US claimed
WO-2022175920-A1 COMBINATION THERAPIES WITH ANTI-CD38 ANTIBODIES AND PARP OR ADENOSINE RECEPTOR INHIBITORS JANSSEN BIOTECH, INC. (US) 2022-08-25 — — WO claimed
WO-2014153424-A1 REDUCING DIABETES IN PATIENTS RECEIVING HMG-COA REDUCTASE INHIBITORS (STATINS) LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY (US) 2014-09-25 — — WO claimed
US-20240219394-A1 METHOD FOR MEASURING RESPONSE OF OLFACTORY RECEPTOR TO SUBSTANCE AJINOMOTO CO., INC. (JP) 2024-07-04 — — US disclosed
US-11857600-B2 GPCR heteromer inhibitors and uses thereof GPCR THERAPEUTICS, INC. (KR) 2024-01-02 — — US disclosed
CN-117321080-A Combination therapy using anti-CD 38 antibodies and PARP or adenosine receptor inhibitors 詹森生物科技公司 2023-12-29 — — CN disclosed
EP-4294844-A1 COMBINATION THERAPIES WITH ANTI-CD38 ANTIBODIES AND PARP OR ADENOSINE RECEPTOR INHIBITORS Janssen Biotech, Inc. (US) 2023-12-27 — — EP disclosed
US-20230181469-A1 MICROPARTICLE FORMULATIONS OF ADENOSINE RECEPTOR ANTAGONISTS FOR TREATING CANCER CYTODIGM, INC. 2023-06-15 — — US disclosed
WO-2023013791-A1 METHOD FOR MEASURING RESPONSE OF OLFACTORY RECEPTOR TO SUBSTANCE 味の素株式会社 2023-02-09 — — WO disclosed
WO-2008131922-A1 NEW 4,8-DIPHENYL-POLYAZANAPHTHALENE DERIVATIVES ALMIRALL, S.A. (ES) 2008-11-06 — — WO disclosed
WO-2008107125-A1 NEW 3-([1,2,4]TRIAZOLO[4,3-A]PYRIDIN-7-YL)BENZAMIDE DERIVATIVES ALMIRALL, S.A. (ES) 2008-09-12 — — WO disclosed
US-7335655-B2 8-heteroaryl xanthine adenosine A2B receptor antagonists KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. (US) 2008-02-26 — — US disclosed
US-7335655-B2 8-heteroaryl xanthine adenosine A2B receptor antagonists KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. (US) 2008-02-26 — — US disclosed
US-7205403-B2 8-Heteroaryl xanthine adenosine A2B receptor antagonists KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. (US) 2007-04-17 — — US disclosed
US-7205403-B2 8-Heteroaryl xanthine adenosine A2B receptor antagonists KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. (US) 2007-04-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220275090-A1 Combination Therapies with Anti-CD38 Antibodies and PARP or Adenosine Receptor Inhibitors CD38, PARP1, PARP11 ADORA2B 38/4885ADORA1 25/4885ADORA2A 16/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback