SCHEMBL1780170

SCHEMBL1780170

CCCn1c(=O)c2[nH]c(-c3cc(OCC(=O)Nc4ccc5c(c4)OCO5)no3)nc2n(CCC)c1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ ADORA2B P29275 20/20 1.00
▸ ADORA1 P30542 8/20 0.77
▸ ADORA2A P29274 1/20 0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14517867 0.88 ADORA2B (0.79) ADORA2BADORA1ADORA2A
SCHEMBL14293825 0.88 ADORA2B (0.81) ADORA2BADORA1ADORA2A
SCHEMBL1222451 0.87 ADORA2B (1.00) ADORA2BADORA1ADORA2A
SCHEMBL1780810 0.87 ADORA2B (1.00) ADORA2BADORA1ADORA2A
SCHEMBL1781047 0.86 ADORA2B (1.00) ADORA2BADORA1ADORA2A
SCHEMBL1779300 0.86 ADORA2B (1.00) ADORA2BADORA1ADORA2A
SCHEMBL4758458 0.80 ADORA2B (1.00) ADORA2BADORA1ADORA2A
SCHEMBL14517874 0.77 ADORA2B (0.82) ADORA2BADORA1ADORA2A
SCHEMBL1779353 0.76 ADORA2B (0.80) ADORA2BADORA1ADORA2A
SCHEMBL5330781 0.74 ADORA2B (0.76) ADORA2BADORA1ADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110118276-A1 METHODS OF TREATING ATHEROSCLEROSIS KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT INC 2011-05-19 — — US claimed
US-7335655-B2 8-heteroaryl xanthine adenosine A2B receptor antagonists KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. (US) 2008-02-26 — — US claimed
US-7205403-B2 8-Heteroaryl xanthine adenosine A2B receptor antagonists KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. (US) 2007-04-17 — — US claimed
US-20060142309-A1 8-Heteroaryl xanthine adenosine A2B receptor antagonists KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. 2006-06-29 — — US claimed
US-20260124327-A1 Compounds Targeting Carbonic Anhydrase IX and Uses Thereof RAYZEBIO, INC. (US) 2026-05-07 — — US disclosed
US-12600742-B2 Markers, conjugates, compositions and methods for hypoxia imaging, mapping, and therapy WWIKY BIOSCIENCES INC. (CA) 2026-04-14 — — US disclosed
EP-4719497-A1 METHODS FOR TREATING SSTR POSITIVE CANCER Rayzebio, Inc. (US) 2026-04-08 — — EP disclosed
US-12583887-B2 PSMA imaging agents SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2026-03-24 — — US disclosed
US-12559521-B2 PSMA imaging agents SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2026-02-24 — — US disclosed
US-20250296971-A1 GASTRIC INHIBITORY PEPTIDE RECEPTOR LIGANDS 3B PHARMACEUTICALS GMBH (DE) 2025-09-25 — — US disclosed
US-20250277211-A1 LPA inhibitors and uses thereof KYLONOVA XIAMEN BIOPHARMA CO LTD (CN) 2025-09-04 — — US disclosed
EP-4610356-A1 RNA INHIBITOR FOR INHIBITING LPA GENE EXPRESSION AND USE THEREOF Kylonova (Xiamen) Biopharma Co., Ltd. (CN) 2025-09-03 — — EP disclosed
US-20220301733-A1 Nuclear Material and Methods FUSION ENERGY SOLUTIONS, INC. 2022-09-22 — — US disclosed
US-11446383-B2 Lipid formulations for delivery of therapeutic agents ARBUTUS BIOPHARMA CORPORATION (CA) 2022-09-20 — — US disclosed
US-20220249710-A1 BIOREDUCTIVELY-ACTIVATED COMPOUNDS, THEIR PRODRUGS, RADIOPHARMACEUTICALS, THE COMPOSITIONS, AND THEIR APPLICATIONS IN MULTIMODAL THERANOSTIC MANAGEMENT OF HYPOXIA DISEASES INCLUDING CANCER WWIKY BIOSCIENCES INC. (CA) 2022-08-11 — — US disclosed
US-11384106-B2 Metal tricarbonyl complexes comprising substituted iminodiactic acid ligands and uses as radioisotope tracers EMORY UNIVERSITY (US) 2022-07-12 — — US disclosed
CN-114703184-A LPA inhibitor and use thereof 厦门甘宝利生物医药有限公司 2022-07-05 — — CN disclosed
CN-114695973-A Preparation method of low-temperature zinc ion battery 电子科技大学 2022-07-01 — — CN disclosed
US-20110118276-A1 METHODS OF TREATING ATHEROSCLEROSIS KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT INC 2011-05-19 — — US disclosed
US-7335655-B2 8-heteroaryl xanthine adenosine A2B receptor antagonists KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. (US) 2008-02-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250296971-A1 GASTRIC INHIBITORY PEPTIDE RECEPTOR LIGANDS GIPR, VIP, GRPR ADORA2B 1117/4885ADORA1 464/4885ADORA2A 1330/4885
US-11446383-B2 Lipid formulations for delivery of therapeutic agents CETP, PNLIP, NPC1L1 ADORA2B 3274/4885ADORA1 2210/4885ADORA2A 2686/4885
US-12559521-B2 PSMA imaging agents KLK3, PSMA1, PSMA6 ADORA2B 3038/4885ADORA1 1313/4885ADORA2A 2713/4885
US-20110118276-A1 METHODS OF TREATING ATHEROSCLEROSIS ADORA2B, ADORA2A, ADORA3 ADORA2B 1/4885ADORA1 4/4885ADORA2A 2/4885
US-12583887-B2 PSMA imaging agents KLK3, PSMA3, PSMA1 ADORA2B 2703/4885ADORA1 1697/4885ADORA2A 2440/4885
US-20220249710-A1 BIOREDUCTIVELY-ACTIVATED COMPOUNDS, THEIR PRODRUGS, RADIOPHARMACEUTICALS, THE COMPOSITIONS, AND THEIR APPLICATIONS IN MULTIMODAL THERANOSTIC MANAGEMENT OF HYPOXIA DISEASES INCLUDING CANCER HIF1A, HIF1AN, PAICS ADORA2B 308/4885ADORA1 191/4885ADORA2A 60/4885
US-12600742-B2 Markers, conjugates, compositions and methods for hypoxia imaging, mapping, and therapy HIF1A, HIF1AN, HYOU1 ADORA2B 868/4885ADORA1 1148/4885ADORA2A 698/4885
US-20260124327-A1 Compounds Targeting Carbonic Anhydrase IX and Uses Thereof CA9, CA13, CA4 ADORA2B 1016/4885ADORA1 1527/4885ADORA2A 2718/4885
US-11384106-B2 Metal tricarbonyl complexes comprising substituted iminodiactic acid ligands and uses as radioisotope tracers SLC16A8, S100A8, FGF23 ADORA2B 1232/4885ADORA1 542/4885ADORA2A 352/4885
US-20060142309-A1 8-Heteroaryl xanthine adenosine A2B receptor antagonists ADORA2B, ADORA2A, ADORA1 ADORA2B 1/4885ADORA1 3/4885ADORA2A 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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