Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7933213 | 0.82 | ALDH1A1 (0.59) | ALDH1A1ALOX15ATMHSD17B10KMT2A | |
| SCHEMBL12226000 | 0.80 | ALDH1A1 (0.56) | ALDH1A1ALOX15ATMHSD17B10THRB | |
| SCHEMBL4073579 | 0.67 | SMN1; SMN2 (0.47) | ALDH1A1ALOX15ATMHSD17B10KMT2A | |
| SCHEMBL7932695 | 0.66 | ALDH1A1 (0.62) | ALDH1A1ATMHSD17B10KMT2AMEN1 | |
| SCHEMBL4205386 | 0.66 | ALDH1A1 (0.49) | ALDH1A1ALOX15ATMHSD17B10THRB | |
| SCHEMBL4201184 | 0.66 | SMN1; SMN2 (0.54) | ALDH1A1ALOX15ATMHSD17B10THRB | |
| SCHEMBL7934631 | 0.65 | ALDH1A1 (0.60) | ALDH1A1ALOX15ATMHSD17B10THRB | |
| SCHEMBL4206007 | 0.65 | SMN1; SMN2 (0.48) | ALDH1A1ALOX15ATMHSD17B10THRB | |
| SCHEMBL4215710 | 0.65 | CNR2 (0.47) | ALDH1A1ALOX15ATMHSD17B10THRB | |
| SCHEMBL13462071 | 0.65 | SMN1; SMN2 (0.59) | ALDH1A1ALOX15ATMHSD17B10THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110257177-A1 | BENZYLTHIOTETRAZOLE INHIBITORS OF STORE OPERATED CALCIUM RELEASE | CALCIMEDICA, INC. (US) | 2011-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110257177-A1 | BENZYLTHIOTETRAZOLE INHIBITORS OF STORE OPERATED CALCIUM RELEASE | SARAF, CACNA1I, ORAI1 | ALDH1A1 4357/4885ALOX15 1429/4885ATM 4057/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.