Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 17/20 | 0.62 |
| ▸ | LMNA | P02545 | 7/20 | 0.62 |
| ▸ | TSHR | P16473 | 7/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | STAT3 | P40763 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7933213 | 0.85 | ALDH1A1 (0.59) | ALDH1A1LMNATSHRRAB9AMAPK1 | |
| SCHEMBL7924146 | 0.79 | ALDH1A1 (0.63) | ALDH1A1LMNATSHRMAPK1MAPT | |
| SCHEMBL1493465 | 0.76 | ALDH1A1 (0.67) | ALDH1A1LMNATSHRRAB9AMAPK1 | |
| SCHEMBL12225960 | 0.75 | ALDH1A1 (0.65) | ALDH1A1LMNATSHRRAB9AMAPK1 | |
| SCHEMBL7924134 | 0.74 | ALDH1A1 (0.54) | ALDH1A1LMNATSHRRAB9AMAPK1 | |
| SCHEMBL2538104 | 0.73 | MEN1 (0.58) | ALDH1A1LMNATSHRRAB9AMAPK1 | |
| SCHEMBL17511445 | 0.71 | ALDH1A1 (0.73) | ALDH1A1LMNATSHRRAB9AMAPK1 | |
| SCHEMBL15786417 | 0.71 | KMT2A (0.55) | ALDH1A1LMNATSHRRAB9AMAPK1 | |
| SCHEMBL2534486 | 0.69 | ALDH1A1 (0.64) | ALDH1A1LMNATSHRRAB9AMAPK1 | |
| SCHEMBL7936398 | 0.69 | LMNA (0.53) | ALDH1A1LMNATSHRMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010034003-A2 | BENZYLTHIOTETRAZOLE INHIBITORS OF STORE OPERATED CALCIUM RELEASE | CALCIMEDICA, INC. (US) | 2010-03-25 | — | — | WO | disclosed |