Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | ABHD6 | Q9BV23 | 2/20 | 0.30 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12226514 | 0.89 | PIK3CD (0.41) | PIK3CDKDM4EPOLBNPC1RAB9A | |
| SCHEMBL12226512 | 0.89 | PIK3CD (0.41) | PIK3CDKDM4EPOLBNPC1RAB9A | |
| SCHEMBL2305763 | 0.86 | PIK3CD (0.48) | PIK3CDKDM4EALDH1A1POLBNPC1 | |
| SCHEMBL13209127 | 0.84 | PIK3CD (0.50) | PIK3CDKDM4EALDH1A1POLBNPC1 | |
| SCHEMBL7805428 | 0.81 | ALDH1A1 (0.42) | ALDH1A1POLB | |
| SCHEMBL21203835 | 0.80 | PIK3CD (0.50) | PIK3CDALDH1A1NPC1RAB9A | |
| SCHEMBL13209129 | 0.79 | PIK3CD (0.46) | PIK3CDKDM4EALDH1A1POLBHSD11B1 | |
| SCHEMBL12226510 | 0.79 | PIK3CD (0.31) | PIK3CD | |
| SCHEMBL7812304 | 0.76 | SLC6A4 (0.36) | — | |
| SCHEMBL28724713 | 0.75 | PIK3CD (0.42) | PIK3CDKDM4EALDH1A1POLBHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8044206-B2 | Nitrogen—containing heterocyclic derivatives having 2,6-disubstituted styryl | ASTELLAS PHARMA INC. (JP) | 2011-10-25 | — | — | US | disclosed |
| US-20070099956-A1 | Nitrogen-containing heterocyclic derivatives having 2, 6-disubstituted styryl | ASTELLAS PHARMA INC. AND KOTOBUKI PHARMACEUTICAL CO., LTD. | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099956-A1 | Nitrogen-containing heterocyclic derivatives having 2, 6-disubstituted styryl | SCN1B, CACNA1B, SCN2A | PIK3CD 921/4885KDM4E 1599/4885ALDH1A1 2549/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.