Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 12/20 | 0.51 |
| ▸ | LONP1 | P36776 | 8/20 | 0.51 |
| ▸ | PSMB11 | A5LHX3 | 7/20 | 0.51 |
| ▸ | PSMA7 | O14818 | 7/20 | 0.51 |
| ▸ | PSMB1 | P20618 | 7/20 | 0.51 |
| ▸ | PSMA1 | P25786 | 7/20 | 0.51 |
| ▸ | PSMA2 | P25787 | 7/20 | 0.51 |
| ▸ | PSMA3 | P25788 | 7/20 | 0.51 |
| ▸ | PSMA4 | P25789 | 7/20 | 0.51 |
| ▸ | PSMB8 | P28062 | 7/20 | 0.51 |
| ▸ | PSMB9 | P28065 | 7/20 | 0.51 |
| ▸ | PSMA5 | P28066 | 7/20 | 0.51 |
| ▸ | PSMB4 | P28070 | 7/20 | 0.51 |
| ▸ | PSMB6 | P28072 | 7/20 | 0.51 |
| ▸ | PSMB10 | P40306 | 7/20 | 0.51 |
| ▸ | PSMB3 | P49720 | 7/20 | 0.51 |
| ▸ | PSMB2 | P49721 | 7/20 | 0.51 |
| ▸ | PSMA6 | P60900 | 7/20 | 0.51 |
| ▸ | PSMA8 | Q8TAA3 | 7/20 | 0.51 |
| ▸ | PSMB7 | Q99436 | 7/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12225848 | 0.87 | PSMB5 (0.54) | PSMB5LONP1PSMB11PSMA7PSMB1 | |
| SCHEMBL12225739 | 0.85 | PSMB5 (0.53) | PSMB5LONP1PSMB11PSMA7PSMB1 | |
| SCHEMBL15184802 | 0.85 | PSMB5 (0.52) | PSMB5LONP1PSMB11PSMA7PSMB1 | |
| SCHEMBL16457746 | 0.84 | MMP2 (0.44) | MMP2MMP9NPY5RADAMTS4F2 | |
| SCHEMBL16457747 | 0.84 | NPY5R (0.47) | MMP2MMP9NPY5RADAMTS4F2 | |
| SCHEMBL19790235 | 0.83 | PSMB5 (0.43) | PSMB5LONP1PSMB11PSMA7PSMB1 | |
| SCHEMBL3135693 | 0.82 | PSMB5 (0.55) | PSMB5LONP1PSMB11PSMA7PSMB1 | |
| SCHEMBL12225588 | 0.82 | PSMB5 (0.51) | PSMB5LONP1PSMB11PSMA7PSMB1 | |
| SCHEMBL2507489 | 0.81 | PSMB5 (0.51) | PSMB5LONP1PSMB11PSMA7PSMB1 | |
| SCHEMBL2509217 | 0.80 | PSMB5 (0.57) | PSMB5LONP1PSMB11PSMA7PSMB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552216-B1 | DERIVATIVES OF 1-AMINO-2-CYCLOPROPYLETHYLBORONIC ACID | MILLENNIUM PHARM INC (US) | 2018-01-24 | — | — | EP | disclosed |
| US-9023832-B2 | Derivatives of 1-amino-2-cyclopropylethylboronic acid | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2015-05-05 | — | — | US | disclosed |
| US-20140179631-A1 | DERIVATIVES OF 1-AMINO-2-CYCLOPROPYLETHYLBORONIC ACID | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-06-26 | — | — | US | disclosed |
| US-20140011998-A1 | DERIVATIVES OF 1-AMINO-2-CYCLOPROPYLETHYLBORONIC ACID | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-01-09 | — | — | US | disclosed |
| US-8513218-B2 | Derivatives of 1-amino-2-cyclopropylethylboronic acid | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-08-20 | — | — | US | disclosed |
| US-8513218-B2 | Derivatives of 1-amino-2-cyclopropylethylboronic acid | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-08-20 | — | — | US | disclosed |
| US-20110245203-A1 | DERIVATIVES OF 1-AMINO-2-CYCLOPROPYLETHYLBORONIC ACID | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140179631-A1 | DERIVATIVES OF 1-AMINO-2-CYCLOPROPYLETHYLBORONIC ACID | PSMB6, PSMB5, PSMB1 | PSMB5 2/4885LONP1 690/4885PSMB11 4/4885 |
| US-20140011998-A1 | DERIVATIVES OF 1-AMINO-2-CYCLOPROPYLETHYLBORONIC ACID | PSMB6, PSMB5, PSMB1 | PSMB5 2/4885LONP1 690/4885PSMB11 4/4885 |
| US-20110245203-A1 | DERIVATIVES OF 1-AMINO-2-CYCLOPROPYLETHYLBORONIC ACID | PSMB6, PSMB5, PSMB1 | PSMB5 2/4885LONP1 690/4885PSMB11 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.