Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.37 |
| ▸ | LDLR | P01130 | 1/20 | 0.35 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.32 |
| ▸ | MERTK | Q12866 | 1/20 | 0.32 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.32 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12229594 | 0.89 | CYP1A2 (0.36) | CYP1A2LDLRPCSK9CYP2C19ALOX15 | |
| SCHEMBL8998779 | 0.88 | CYP1A2 (0.36) | CYP1A2LDLRPCSK9CYP2C19LRRK2 | |
| SCHEMBL8998949 | 0.87 | CYP1A2 (0.38) | CYP1A2CYP2C19LRRK2ALOX15FLT3 | |
| SCHEMBL8998750 | 0.83 | CYP1A2 (0.37) | CYP1A2LDLRPCSK9CYP2C19ALOX15 | |
| SCHEMBL13953990 | 0.83 | CYP1A2 (0.37) | CYP1A2LDLRPCSK9CYP2C19ALOX15 | |
| SCHEMBL12229675 | 0.80 | LMNA (0.32) | CYP1A2POLBALDH1A1CYP2C9MAPK1 | |
| SCHEMBL8999560 | 0.77 | P4HTM (0.43) | CYP1A2LRRK2ALOX15HRH4ALDH1A1 | |
| SCHEMBL8998786 | 0.77 | CYP1A2 (0.35) | CYP1A2LDLRPCSK9CYP2C19ALOX15 | |
| SCHEMBL13752544 | 0.74 | CYP1A2 (0.35) | CYP1A2CYP2C19LRRK2ALOX15FLT3 | |
| SCHEMBL8998497 | 0.74 | HRH4 (0.35) | LDLRPCSK9MAPTHRH4RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8034832-B2 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-10-11 | — | — | US | disclosed |
| US-20090325935-A1 | GYRASE INHIBITORS AND USES THEREOF | VERTEX PHARMACEUTICALS INCORPORATED | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325935-A1 | GYRASE INHIBITORS AND USES THEREOF | TOP1, TOP2A, TOP2B | CYP1A2 1272/4885LDLR 4388/4885PCSK9 1323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.