SCHEMBL12237707

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL4491083	0.90	ROCK2 (0.37)	ROCK2KMT2AMAPTMAOAMAOB
	SCHEMBL4491081	0.90	ROCK2 (0.37)	ROCK2KMT2AMAPTMAOAMAOB
	SCHEMBL3157925	0.89	ROCK2 (0.43)	ROCK2HDAC1LSSCYP3A4CYP2C19
	SCHEMBL15425751	0.89	ROCK2 (0.37)	ROCK2MAOAMAOBHDAC1LSS
	SCHEMBL15408466	0.89	ROCK2 (0.37)	ROCK2MAOAMAOBHDAC1LSS
	SCHEMBL4487046	0.89	LSS (0.44)	ROCK2MAPTLSS
	SCHEMBL15408464	0.89	ROCK2 (0.37)	ROCK2MAOAMAOBHDAC1LSS
	SCHEMBL4504089	0.89	BACE1 (0.43)	ROCK2TP53MAPTSMN1; SMN2MAOA
	SCHEMBL3157931	0.89	ROCK2 (0.43)	ROCK2HDAC1LSSCYP3A4CYP2C19
	SCHEMBL4504092	0.89	BACE1 (0.43)	ROCK2TP53MAPTSMN1; SMN2MAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.