Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 7/20 | 0.57 |
| ▸ | FOLR1 | P15328 | 2/20 | 0.57 |
| ▸ | SLC19A1 | P41440 | 2/20 | 0.57 |
| ▸ | SLC46A1 | Q96NT5 | 2/20 | 0.57 |
| ▸ | DHFR | P00374 | 1/20 | 0.57 |
| ▸ | FOLR2 | P14207 | 1/20 | 0.57 |
| ▸ | GART | P22102 | 1/20 | 0.57 |
| ▸ | ATIC | P31939 | 1/20 | 0.57 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.57 |
| ▸ | FRK | P42685 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22967337 | 0.87 | TYMS (0.59) | TYMSFOLR1SLC19A1SLC46A1DHFR | |
| SCHEMBL24845716 | 0.86 | PNP (0.57) | TYMSFOLR1SLC19A1SLC46A1DHFR | |
| SCHEMBL24845712 | 0.86 | TYMS (0.56) | TYMSFOLR1SLC19A1SLC46A1DHFR | |
| SCHEMBL13659935 | 0.85 | TYMS (0.63) | TYMSFOLR1SLC19A1SLC46A1DHFR | |
| SCHEMBL18755599 | 0.85 | TYMS (0.55) | TYMSFOLR1SLC19A1SLC46A1DHFR | |
| SCHEMBL2260428 | 0.84 | TYMS (0.69) | TYMSFOLR1SLC19A1SLC46A1DHFR | |
| SCHEMBL18551642 | 0.84 | TYMS (0.64) | TYMSFOLR1SLC19A1SLC46A1DHFR | |
| SCHEMBL2261493 | 0.84 | TYMS (0.55) | TYMSFOLR1SLC19A1SLC46A1DHFR | |
| SCHEMBL25476851 | 0.83 | TYMS (0.64) | TYMSFOLR1SLC19A1SLC46A1DHFR | |
| SCHEMBL13524779 | 0.83 | TYMS (0.67) | TYMSFOLR1SLC19A1SLC46A1DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021026310-A1 | PROCESSES OF PREPARING POLYGLUTAMATED ANTIFOLATES AND USES OF THEIR COMPOSITIONS | L.E.A.F. HOLDINGS GROUP LLC (US) | 2021-02-11 | — | — | WO | disclosed |
| EP-3035938-B1 | TARGETED THERAPEUTICS | MADRIGAL PHARMACEUTICALS INC (US) | 2020-08-19 | — | — | EP | disclosed |
| US-8362245-B2 | Processes for preparing intermediates of pemetrexed | SICOR INC. (US) | 2013-01-29 | — | — | US | disclosed |
| US-20110263851-A1 | PROCESSES FOR PREPARING INTERMEDIATES OF PEMETREXED | SICOR INC. (US) | 2011-10-27 | — | — | US | disclosed |
| US-7994180-B2 | prepared, preferably in high purity, via a straight-forward process without the need for the purification of intermediates | SICOR INC. (US) | 2011-08-09 | — | — | US | disclosed |
| US-20080146799-A1 | prepared, preferably in high purity, via a straight-forward process without the need for the purification of intermediates | ASSIA CHEMICAL INDUSTRIES LTD. (IL) | 2008-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263851-A1 | PROCESSES FOR PREPARING INTERMEDIATES OF PEMETREXED | DPYD, TYMP, TYMS | TYMS 3/4885FOLR1 48/4885SLC19A1 171/4885 |
| US-20080146799-A1 | prepared, preferably in high purity, via a straight-forward process without the need for the purification of intermediates | TYMP, TYMS, DHFR | TYMS 2/4885FOLR1 33/4885SLC19A1 63/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.